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Titolo:
MEMORY REPRESENTATION WITHIN THE PARAHIPPOCAMPAL REGION
Autore:
YOUNG BJ; OTTO T; FOX GD; EICHENBAUM H;
Indirizzi:
BOSTON UNIV,DEPT PSYCHOL,COGNIT NEUROBIOL LAB,64 CUMMINGTON ST BOSTONMA 02215 BOSTON UNIV,DEPT PSYCHOL,COGNIT NEUROBIOL LAB BOSTON MA 02215 UNIV OTAGO,DEPT PSYCHOL DUNEDIN NEW ZEALAND RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08901 UNIV N CAROLINA,DEPT PSYCHOL CHAPEL HILL NC 27599
Titolo Testata:
The Journal of neuroscience
fascicolo: 13, volume: 17, anno: 1997,
pagine: 5183 - 5195
SICI:
0270-6474(1997)17:13<5183:MRWTPR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR TEMPORAL CORTEX; SHORT-TERM-MEMORY; VISUAL RECOGNITION MEMORY; OBJECT-RECOGNITION; NEURONAL-ACTIVITY; WORKING MEMORY; RHINAL CORTEX; HIPPOCAMPAL-FORMATION; FORNIX TRANSECTION; PERIRHINAL CORTEX;
Keywords:
ENTORHINAL CORTEX; PERIRHINAL CORTEX; SUBICULUM; HIPPOCAMPUS; RECOGNITION MEMORY; DELAYED NONMATCHING; SINGLE UNITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Young et al., "MEMORY REPRESENTATION WITHIN THE PARAHIPPOCAMPAL REGION", The Journal of neuroscience, 17(13), 1997, pp. 5183-5195

Abstract

The activity of 378 single neurons was recorded from areas of the parahippocampal region (PHR), including the perirhinal and lateral entorhinal cortex, as well as the subiculum, in rats performing an odor-guided delayed nonmatching-to-sample task. Nearly every neuron fired in association with some trial event, and every identifiable trial event orbehavior was encoded by neuronal activity in the PHR. The greatest proportion of cells was active during odor sampling, and for many cells,activity during this period was odor selective. In addition, odor memory coding was reflected in two general ways. First, a substantial proportion of cells showed odor-selective activity throughout or at the end of the memory delay period. Second, odor-responsive cells showed odor-selective enhancement or suppression of activity during stimulus repetition in the recognition phase of the task. These data, combined with evidence that the PHR is critical for maintaining odor memories in animals performing the same task, indicate that this cortical region mediates the encoding of specific memory cues, maintains stimulus representations, and supports specific match-nonmatch judgments critical torecognition memory. By contrast, hippocampal neurons do not demonstrate evoked or maintained stimulus-specific codings, and hippocampal damage results in little if any decrement in performance on this task. Thus it becomes increasingly clear that the parahippocampal cortex can support recognition memory independent of the distinct memory functionsof the hippocampus itself.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:38:34