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Titolo:
Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography
Autore:
Okubo, Y; Suhara, T; Suzuki, K; Kobayashi, K; Inoue, O; Terasaki, O; Someya, Y; Sassa, T; Sudo, Y; Matsushima, E; Iyo, M; Tateno, Y; Toru, M;
Indirizzi:
Tokyo Med & Dent Univ, Grad Sch, Div Cignit & Behav Med,Dept Neurobehav Med, Sect Psychiat & Behav Sci,Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Inage Ku, Chiba 2638555, Japan Natl Inst Radiol Sci Chiba Japan 2638555 Inage Ku, Chiba 2638555, Japan Japan Sci & Technol Corp, CREST, Yokohama, Kanagawa, Japan Japan Sci & Technol Corp Yokohama Kanagawa Japan kohama, Kanagawa, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 25, volume: 66, anno: 2000,
pagine: 2455 - 2464
SICI:
0024-3205(20000512)66:25<2455:S5RISP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; DOPAMINE D1 RECEPTORS; RAT CEREBRAL-CORTEX; LIVING HUMAN-BRAIN; FRONTAL-CORTEX; H-3 RACLOPRIDE; BINDING; PET; CLOZAPINE; D-2;
Keywords:
5-HT2 receptors; positron emission tomography; [C-11]N-methylspiperone; schizophrenia; prefrontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Okubo, Y Tokyo Med & Dent Univ, Grad Sch, Div Cignit & Behav Med,Dept Neurobehav Med, Sect Psychiat & Behav Sci,Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138519 , Japan
Citazione:
Y. Okubo et al., "Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography", LIFE SCI, 66(25), 2000, pp. 2455-2464

Abstract

Using positron emission tomography (PET) and [C-11]N-methylspiperone (NMSP), we examined 5-HT2 receptors in the cortex of schizophrenic patients in whom we previously observed decereased prefrontal D1 receptor binding. The subjects were 10 neuroleptic-naive schizophrenic patients, 7 schizophrenic patients who were drug-free but had previously been treated with neuroleptics, and 12 normal controls. A non-significant trend towards decreased prefrontal [C-11]NMSP binding was observed in the neuroleptic-treated patients, suggesting a possible effect of previous neuroleptic treatment on the alteration in cortical 5-HT2 function. However, the neuroleptic-naive patients showed no noticeable difference in cortical [C-11]NMSP binding compared to controls. Our results do not rule out the role of 5-HT2 function as a crucialsite of therapeutic activity of schizophrenia, but they do suggest that cortical 5-HT2 receptors might not be primarily involved in the pathophysiology of schizophrenia.

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Documento generato il 27/01/20 alle ore 13:57:41