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Titolo:
The specificity of platelet glutamate receptor supersensitivity in psychotic disorders
Autore:
Berk, M; Plein, H; Belsham, B;
Indirizzi:
Univ Witwatersrand, Fac Hlth Sci, Dept Psychiat, ZA-2193 Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa ZA-2193 sburg, South Africa Univ Witwatersrand, Dept Clin & Expt Pharmacol, ZA-2193 Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa ZA-2193 sburg, South Africa
Titolo Testata:
LIFE SCIENCES
fascicolo: 25, volume: 66, anno: 2000,
pagine: 2427 - 2432
SICI:
0024-3205(20000512)66:25<2427:TSOPGR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR CALCIUM; DOUBLE-BLIND; SCHIZOPHRENIA; DEPRESSION; MODEL; SEROTONIN; GLYCINE;
Keywords:
schizophrenia; mania; depression; psychosis; platelet intracellular calcium response; glutamate; receptor supersensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M Univ Witwatersrand, Fac Hlth Sci, Dept Psychiat, ZA-2193 Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa ZA-2193 outh Africa
Citazione:
M. Berk et al., "The specificity of platelet glutamate receptor supersensitivity in psychotic disorders", LIFE SCI, 66(25), 2000, pp. 2427-2432

Abstract

Hypoglutamatergic function is implicated in the pathogenesis of schizophrenia, and supersensitivity of platelet NMDA receptors has been reported in schizophrenia. The aim of this study was to examine the platelet glutamate receptor sensitivity in patients with schizophrenia (n=12), mania with psychotic features (n=10) and depression with psychotic features (n=10) and matched controls (n=12) in order to assess if this is a marker of schizophreniaor occurs in other psychotic conditions. Glutamate receptor sensitivity was assessed using the intracellular calcium response to glutamate measured with spectroflourometry. The percentage response of the schizophrenic and depressed psychotic subjects to glutamate stimulation was significantly greater than control subjects (p<0.005). The mania with psychotic features groupwas not significantly different to controls. This data suggests that platelet glutamate receptors may be supersensitive in schizophrenia and depression with psychotic features. Furthermore, the platelet may be a possible peripheral marker of glutamate function in schizophrenia and depression with psychotic features.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:29:20