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Titolo:
Myelodysplastic syndrome at a large tertiary care community hospital: analysis according to the international prognostic scoring system
Autore:
Jaiyesimi, IA; Friedline, JA; Mattson, JC; Gyorfi, T; Davis, BH; Balasubramaniam, M; Al-Khalili, A; Burdakin, J; Decker, D; Zakalik, D; Neumann, K; Wilner, F;
Indirizzi:
William Beaumont Hosp, Dept Clin Pathol, Royal Oak, MI 48073 USA William Beaumont Hosp Royal Oak MI USA 48073 hol, Royal Oak, MI 48073 USA William Beaumont Hosp, Dept Med, Div Hematol Oncol, Royal Oak, MI 48073 USA William Beaumont Hosp Royal Oak MI USA 48073 col, Royal Oak, MI 48073 USA William Beaumont Hosp, Res Inst, Off Biostat, Royal Oak, MI 48073 USA William Beaumont Hosp Royal Oak MI USA 48073 tat, Royal Oak, MI 48073 USA
Titolo Testata:
LEUKEMIA RESEARCH
fascicolo: 5, volume: 24, anno: 2000,
pagine: 417 - 426
SICI:
0145-2126(200005)24:5<417:MSAALT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPOSALS; CLASSIFICATION; LEUKEMIA;
Keywords:
International Prognostic Scoring System; myelodysplasia; acute myeloid leukemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Mattson, JC William Beaumont Hosp, Dept Clin Pathol, 3601 W 13 Mile Rd, Royal Oak, MI 48073 USA William Beaumont Hosp 3601 W 13 Mile Rd Royal Oak MI USA 48073
Citazione:
I.A. Jaiyesimi et al., "Myelodysplastic syndrome at a large tertiary care community hospital: analysis according to the international prognostic scoring system", LEUK RES, 24(5), 2000, pp. 417-426

Abstract

The outcome of patients diagnosed with primary myelodysplastic syndromes (MDS) between 1990 and 1997 from William Beaumont Hospital (WBH) was analyzed according to the International Prognostic Scoring System (IPSS) risk categorization. A retrospective study of 195 MDS patients was performed. Seventy-nine patients with MDS, in whom a karyotype was obtained and with an adequate follow-up were included in the final analysis. Cases of proliferative CMML (WBC > 12 x 10(9)/1) were excluded from the study. The overall median survival was 3.1 years, and median survival stratified by IPSS was 3.4, 4.1and 0.5 years for the INT-1, INT-2 and high risk group and not yet reachedfor the low risk group. The overall survival by IPSS subcategorization were 6.88, 5.29, 5.30 and 2.12 years for the low, INT-1, INT-2, and high risk groups respectively. Cytogenetics were significant in predicting the overall survival. The IPSS score stratified patients into risk categories for development of AML. The risk of development into AML was 8, 8, 33 and 54% for the low, INT-1, INT-2 and high risk groups, respectively. We conclude that IPSS score can be useful in predicting survival and AML evolution in some MDS patients. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:10:47