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Titolo:
Difference in the responses after administration of granulocyte colony-stimulating factor in septic patients with relative neutropenia
Autore:
Ishikawa, K; Tanaka, H; Nakamori, Y; Hosotsubo, H; Ogura, H; Nishino, M; Shimazu, T; Sugimoto, H;
Indirizzi:
Osaka Univ, Sch Med, Dept Traumatol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 aumatol, Suita, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
fascicolo: 5, volume: 48, anno: 2000,
pagine: 814 - 824
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST TRIAL; NECROSIS-FACTOR-ALPHA; VERSUS-HOST DISEASE; G-CSF; INFECTIOUS-DISEASES; MULTICENTER TRIAL; AMPHOTERICIN-B; T-LYMPHOCYTES; DOUBLE-BLIND; PHASE-III;
Keywords:
granulocyte colony-stimulating factor (G-CSF); neutropenia; sepsis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, H Osaka Univ, Sch Med, Dept Traumatol, 2-15 Yamadaoka, Suita, Osaka 5650871,Japan Osaka Univ 2-15 Yamadaoka Suita Osaka Japan 5650871 650871,Japan
Citazione:
K. Ishikawa et al., "Difference in the responses after administration of granulocyte colony-stimulating factor in septic patients with relative neutropenia", J TRAUMA, 48(5), 2000, pp. 814-824

Abstract

Objective: The objective of this study was to classify the clinical responses after administration of granulocyte colony-stimulating factor (G-CSF) in septic patients with relative neutropenia. Patients and Methods: We administered recombinant human G-CSF (2 mu g/kg) subcutaneously once a day for 5 days to 30 septic patients with white cell counts below 5,000 cells/mm(3). Absolute neutrophil count (ANC), neutrophildifferentiation, and serum concentration of G-CSF were determined serially. Bone marrow also was analyzed before and after treatment. Results: Neutrophil responses to G-CSF varied from good (ANC > 10,000/mm(3), group G, n = 20) to moderate (ANC < 10,000/mm(3), group M, n = 5) to poor (no increase in ANC, group P, n = 5). Before G-CSF administration, the three groups showed no differences in ANC but did show significant differences in serum concentration of G-CSF. G-CSF concentration was 0.16 +/- 0.03 ng/mL in group G, 7.0 +/- 3.0 ng/mL in group M, and 270 +/- 90 ng/mL in groupP. Immature neutrophils accounted for 35.0 +/- 3.7% of peripheral leukocytes in group P but only 5.1 +/- 0.6% in group G. Although bone marrow was depressed in all groups before C-CSF treatment, nucleated cell count increased significantly after rhG-CSF treatment in groups G and M. Survival rate after 4 weeks was 90% in group G and 100% in group M; no patient in group P survived. Conclusion: G-CSF administration was effective in septic patients with a low percentage of immature neutrophils and insufficient endogenous G-CSF, Ithad little effect on patients with a high percentage of immature neutrophils whose C-CSF production was up-regulated and whose bone marrow,vas severely depressed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:55:11