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Titolo:
Electrocardiographic assessment of antianxiety medication in dogs and correlation with serum drug concentration
Autore:
Reich, MR; Ohad, DG; Overall, KL; Dunham, AE;
Indirizzi:
Univ Penn, Sch Vet Med, Dept Clin Studies, Philadelphia, PA 19104 USA UnivPenn Philadelphia PA USA 19104 n Studies, Philadelphia, PA 19104 USA Univ Penn, Sch Vet Med, Dept Cardiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Cardiol, Philadelphia, PA 19104 USA Univ Penn, Sch Arts & Sci, Dept Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dept Biol, Philadelphia, PA 19104 USA Univ Penn, Sch Vet Med, Dept Cardiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Cardiol, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
fascicolo: 10, volume: 216, anno: 2000,
pagine: 1571 - 1575
SICI:
0003-1488(20000515)216:10<1571:EAOAMI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
QT(C) INTERVAL PROLONGATION; TRICYCLIC ANTI-DEPRESSANTS; ANIMAL SHELTER; QT INTERVAL; ANTIDEPRESSANTS; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Reich, MR Univ Penn, Sch Vet Med, Dept Clin Studies, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Philadelphia, PA 19104 USA
Citazione:
M.R. Reich et al., "Electrocardiographic assessment of antianxiety medication in dogs and correlation with serum drug concentration", J AM VET ME, 216(10), 2000, pp. 1571-1575

Abstract

Objectives-To determine effects of tricyclic antidepressants (TCA) on the ECG of dogs treated for behavioral conditions and to examine correlations between ECG findings and serum concentrations of these medications. Design-Repeated-measures study. Animals-39 client-owned dogs with behavioral problems. Procedure-Two groups of dogs with behavioral problems were evaluated. In group 1 (n = 20), ECG tracings were recorded before starting treatment with TCA and again after treatment for greater than or equal to 1 month. Dogs ingroup 2 were already on long-term maintenance amounts of antianxiety medication when ECG tracings were recorded and serum concentrations of medications were obtained. Results-Significant differences were not detected for dogs in group 1 between ECG values measured before and after TCA administration. The ECG valuesfor dogs in group 2 did not differ significantly from the mean of group-1 dogs before receiving medication or from the reference range used at our facility. Duration of the P wave had a significant positive correlation with serum concentrations of clomipramine but significant negative correlation with serum concentrations of amitriptyline. The QT interval corrected for heart rate had a significant negative correlation with serum concentrations of amitriptyline. Conclusions and Clinical Relevance-Amitriptyline and clomipramine administered at standard dosages apparently do not cause ECG abnormalities in healthy dogs with behavioral problems. These medications should be used cautiously in dogs with conduction abnormalities, and clinicians should periodically monitor ECG and use good clinical judgment to weigh risks and benefits ofmedications for the safety of each dog.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:19:05