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Titolo:
Changes in lipid peroxidation during pregnancy and after delivery in rats:effect of pinealectomy
Autore:
Sainz, RM; Reiter, RJ; Mayo, JC; Cabrera, J; Tan, DX; Qi, W; Garcia, JJ;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 truct Biol, San Antonio, TX 78229 USA
Titolo Testata:
JOURNAL OF REPRODUCTION AND FERTILITY
fascicolo: 1, volume: 119, anno: 2000,
pagine: 143 - 149
SICI:
0022-4251(200005)119:1<143:CILPDP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; NITRIC-OXIDE; VITAMIN-E; IN-VITRO; UMBILICAL ARTERY; HUMAN PLACENTA; MELATONIN; PREECLAMPSIA; DAMAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Reiter, RJ Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, Mail Code 7762,7703Floyd Curl Dr, San Antonio, TX 78229 USA Univ Texas Mail Code 7762,7703 Floyd Curl Dr San Antonio TX USA 78229
Citazione:
R.M. Sainz et al., "Changes in lipid peroxidation during pregnancy and after delivery in rats:effect of pinealectomy", J REPR FERT, 119(1), 2000, pp. 143-149

Abstract

Pregnancy is a physiological state accompanied by a high energy demand of many bodily functions and an increased oxygen requirement. Because of the increased intake and utilization of oxygen, increased levels of oxidative stress would be expected. In the present study, the degree of lipid peroxidation was examined in different tissues from non-pregnant and pregnant rats after the delivery of their young. Melatonin and other indole metabolites are known to be direct free radical scavengers and indirect antioxidants. Thus the effect of pinealectomy at 1 month before pregnancy on the accumulation of lipid damage was investigated in non-pregnant and pregnant rats after the delivery of their young. Malonaldehyde and 4-hydroxyalkenal concentrations were measured in the lung, uterus, liver, brain, kidney, thymus and spleen from intact and pinealectomized pregnant rats soon after birth of theiryoung and at 14 and 21 days after delivery. The same parameters were also evaluated in intact and pinealectomized non-pregnant rats. Shortly after delivery, lipid oxidative damage was increased in lung, uterus, brain, kidneyand thymus of the mothers. No differences were detected in liver and spleen. Pinealectomy enhanced this effect in the uterus and lung. It is concluded that during pregnancy high levels of oxidative stress induce an increase in oxidative damage to lipids, which in some cases is inhibited by the antioxidative actions of pineal indoles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:23:32