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Titolo:
EXPRESSION OF THE T-CELL ACTIVATION ANTIGEN, OX-40, IDENTIFIES ALLOREACTIVE T-CELLS IN ACUTE GRAFT-VERSUS-HOST DISEASE
Autore:
TITTLE TV; WEINBERG AD; STEINKELER CN; MAZIARZ RT;
Indirizzi:
OREGON HLTH SCI UNIV,DIV HEMATOL & MED ONCOL,OHSU L580,3181 SW SAM JACKSON PK RD PORTLAND OR 97201 OREGON HLTH SCI UNIV,DIV HEMATOL & MED ONCOL PORTLAND OR 97201 PROVIDENCE MED CTR,EARLE A CHILES RES INST PORTLAND OR 00000 OREGON HLTH SCI UNIV,DIV HEMATOL & MED ONCOL PORTLAND OR 97201 VET AFFAIRS MED CTR PORTLAND OR 00000
Titolo Testata:
Blood
fascicolo: 12, volume: 89, anno: 1997,
pagine: 4652 - 4658
SICI:
0006-4971(1997)89:12<4652:EOTTAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; MINOR HISTOCOMPATIBILITY ANTIGEN; RECEPTOR MONOCLONAL-ANTIBODY; OX40 LIGAND; MURINE; LYMPHOCYTES; MICE; COMPLEX; PROPHYLAXIS; MOLECULE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
T.V. Tittle et al., "EXPRESSION OF THE T-CELL ACTIVATION ANTIGEN, OX-40, IDENTIFIES ALLOREACTIVE T-CELLS IN ACUTE GRAFT-VERSUS-HOST DISEASE", Blood, 89(12), 1997, pp. 4652-4658

Abstract

The OX-40 molecule is expressed on the surface of recently activated T lymphocytes, The presence of OX-40 on CD4(+) T cells was analyzed ina rat haplo-identical (parental --> F1) bone marrow transplant model of acute graft-versus-host disease (aGVHD), Increased numbers of activated CD4(+) T cells that expressed the OX-40 antigen were detected in peripheral blood soon after transplantation before the earliest sign of disease. The peak of OX-40 expression occurred 12 days posttransplantation with a range of 18% to 36% of circulating T cells and remained 10-fold above background, never returning to baseline, A slight increase in OX-40 expression (range, 1% to 6%) was also detected on peripheral blood lymphocytes from control syngeneic Fl --> Fl recipients, OX-40(+) T cells were isolated from spleen, skin, lymph node, end liver tissue of rats undergoing aGVHD, but not in syngeneic transplants, OX-40(+) T cells isolated from these tissues were of donor origin and were shown to be alloreactive, These data raise the possibility of using the OX-40 antibody to detect and deplete selectively the T cells that cause aGVHD. (C) 1997 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 17:19:33