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Titolo:
Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo
Autore:
Martin, M; Macias, M; Escames, G; Reiter, RJ; Agapito, MT; Ortiz, GG; Acuna-Castroviejo, D;
Indirizzi:
Univ Granada, Dept Fisiol, Fac Med, Inst Biotecnol, E-18012 Granada, SpainUniv Granada Granada Spain E-18012 nst Biotecnol, E-18012 Granada, Spain Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 truct Biol, San Antonio, TX 78284 USA Univ Valladolid, Dept Bioquim & Biol Mol, Valladolid, Spain Univ Valladolid Valladolid Spain Bioquim & Biol Mol, Valladolid, Spain
Titolo Testata:
JOURNAL OF PINEAL RESEARCH
fascicolo: 4, volume: 28, anno: 2000,
pagine: 242 - 248
SICI:
0742-3098(200005)28:4<242:MIAOTR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION; ENERGY-METABOLISM; OXIDATIVE DAMAGE; ANTIOXIDANT; PROTECTION; TISSUES; VITRO; MICE; RAT;
Keywords:
cytotoxicity; electron transport chain; melatonin; mitochondria; oxidative stress; ruthenium red;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Acuna-Castroviejo, D Univ Granada, Dept Fisiol, Fac Med, Inst Biotecnol, Avda Madrid 11, E-18012 Granada, Spain Univ Granada Avda Madrid 11 Granada Spain E-18012 in
Citazione:
M. Martin et al., "Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo", J PINEAL R, 28(4), 2000, pp. 242-248

Abstract

Melatonin displays antioxidant and free radical scavenger properties. Due to its ability with which it enters cells, these protective effects are manifested in all subcellular compartments. Recent studies suggest a role for melatonin in mitochondrial metabolism. To study the effects of melatonin onthis organelle we used ruthenium red to induce mitochondrial damage and oxidative stress. The results show that melatonin (10 mg/kg i.p.) can increase the activity of the mitochondrial respiratory complexes I and IV after its administration in vivo in a time-dependent manner; these changes correlate well with the half-life of the indole in plasma. Melatonin administrationalso prevented the decrease in the activity of complexes I and IV due to ruthenium red (60 mu g/kg i.p.) administration. At this dose, ruthenium red did not induce lipid peroxidation but it significantly reduced the activityof the antioxidative enzyme glutathione peroxidase, an effect also counteracted by melatonin. These results suggest that melatonin modulates mitochondrial respiratory activity, an effect that may account for some of the protective properties of the indoleamine. The mitochondria-modulating role of melatonin may be of physiological significance since it seems that the indoleamine is concentrated into normal mitochondria. The data also support a pharmacological use of melatonin in drug-induced mitochondrial damage in vivo.

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Documento generato il 28/01/20 alle ore 14:51:47