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Titolo:
Orbital and dorsolateral frontal perfusion defect associated with behavioral response to cholinesterase inhibitor therapy in Alzheimer's disease
Autore:
Mega, MS; Dinov, ID; Lee, L; OConnor, SM; Masterman, DM; Wilen, B; Mishkin, F; Toga, AW; Cummings, JL;
Indirizzi:
Univ Calif Los Angeles, Rush Alzheimers Dis Ctr, Sch Med, Dept Neurol,Lab Neuro Imaging, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Rush Alzheimers Dis Ctr, Dept Nucl Med Harbor, LabNeuro Imaging, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 2, volume: 12, anno: 2000,
pagine: 209 - 218
SICI:
0895-0172(200021)12:2<209:OADFPD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHYSOSTIGMINE; TOMOGRAPHY; METABOLISM; DELUSIONS; DEMENTIA; SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Mega, MS Univ Calif Los Angeles, Rush Alzheimers Dis Ctr, Sch Med, Dept Neurol,Lab Neuro Imaging, 710 Westwood Plaza, Los Angeles, CA 90095 USA Univ Calif Los Angeles 710 Westwood Plaza Los Angeles CA USA 90095
Citazione:
M.S. Mega et al., "Orbital and dorsolateral frontal perfusion defect associated with behavioral response to cholinesterase inhibitor therapy in Alzheimer's disease", J NEUROP CL, 12(2), 2000, pp. 209-218

Abstract

The authors retrospectively explored the behavioral and functional imagingprofile of Alzheimer's disease (AD) patients who respond to cholinesteraseinhibitor therapy by using the Neuropsychiatric Inventory (NPI) and baseline [Tc-99m] HMPAO SPECT. Thirty AD patients were divided into three groups (Responders, Nonresponders, and Unchanged) based on their behavioral response to donepezil. Responders had significantly (P less than or equal to 0.01) move pretreatment irritability, disinhibition (P less than or equal to 0.05), and euphoria (P=0.05) than Nonresponders and significantly lower lateral orbital frontal (P<0.00001) and dorsolateral frontal (P less than or equal to 0.0005) perfusion bilaterally. A pretreatment orbitofrontal syndrome may predict behavioral response to cholinesterase inhibitor therapy in AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:21:24