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Titolo:
Carotid atherosclerosis and cerebral white matter lesions in a population based magnetic resonance imaging study
Autore:
de Leeuw, FE; de Groot, JC; Bots, ML; Witteman, JCM; Oudkerk, M; Hofman, A; van Gijn, J; Breteler, MMB;
Indirizzi:
Erasmus Med Ctr Rotterdam, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam,Netherlands Erasmus Med Ctr Rotterdam Rotterdam Netherlands NL-3000 DR m,Netherlands Univ Med Ctr Utrecht, Julius Ctr Patient Oriented Res, Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands nted Res, Utrecht, Netherlands Erasmus Med Ctr Rotterdam, Daniel den Hoed Canc Clin, Dept Radiol, Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Rotterdam Netherlands Rotterdam, Netherlands Univ Med Ctr Utrecht, Dept Neurol, Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands t Neurol, Utrecht, Netherlands
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 4, volume: 247, anno: 2000,
pagine: 291 - 296
SICI:
0340-5354(200004)247:4<291:CAACWM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTIMA-MEDIA THICKNESS; ARTERIAL-WALL THICKNESS; CORONARY HEART-DISEASE; VASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; ULTRASOUND MEASUREMENT; BLOOD-PRESSURE; ROTTERDAM; DEMENTIA; MRI;
Keywords:
leukoaraiosis; aged; atherosclerosis; magnetic resonance imaging; carotid artery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Breteler, MMB Erasmus Med Ctr Rotterdam, Dept Epidemiol & Biostat, NL-3000DR Rotterdam,Netherlands Erasmus Med Ctr Rotterdam Rotterdam NetherlandsNL-3000 DR
Citazione:
F.E. de Leeuw et al., "Carotid atherosclerosis and cerebral white matter lesions in a population based magnetic resonance imaging study", J NEUROL, 247(4), 2000, pp. 291-296

Abstract

Cerebral white matter lesions are frequently observed on magnetic resonance imaging of elderly, nondemented persons. There is evidence that white matter lesions are involved in the pathophysiology of cognitive decline and dementia. White matter lesions can be divided into those in the periventricular and those in the subcortical region. Pathological and epidemiological studies suggest that atherosclerosis is involved in the pathogenesis of theselesions. Our study reports on the association between atherosclerosis in the carotid arteries and white matter lesions in a population-based study among 1077 elderly subjects. We randomly sampled 1077 subjects aged between 60-90 years from two prospective population-based studies. All subjects underwent ultrasonography of the carotid artery. In addition, 1.5 T magnetic resonance imaging was performed; white matter lesions in the subcortical and periventricular regions were rated separately. With increasing number of plaques in the carotid artery the severity of periventricular white matter lesions increased (P-trend = 0.03), but not the severity of subcortical whitematter lesions (P-trend = 0.19). In addition, an increase in intima media thickness was borderline significantly associated with an increased severity of periventricular white matter lesions (P-trend = 0.09), but not of subcortical white matter lesions (P-trend = 0.68). These findings suggest that partly dissimilar pathogenetic mechanisms are involved in the etiology of periventricular and subcortical white matter lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:13:33