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Titolo:
Preclinical (premotor) Parkinson's disease
Autore:
Wolters, EC; Francot, C; Bergmans, P; Winogrodzka, A; Booij, J; Berendse, HW; Stoof, JC;
Indirizzi:
Vrije Univ Amsterdam, Acad Ziekenhuis, Dept Neurol, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands
Titolo Testata:
JOURNAL OF NEUROLOGY
, volume: 247, anno: 2000, supplemento:, 2
pagine: 103 - 109
SICI:
0340-5354(200004)247:<103:P(PD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; STRIATAL DOPAMINE TRANSPORTERS; FIRST-DEGREE RELATIVES; OLFACTORY DYSFUNCTION; COGNITIVE DEFICITS; WORKING-MEMORY; SPECT; DEPRESSION; BINDING; STAGE;
Keywords:
olfaction; smell; hyposmia; [I-123]beta-CIT SPECT; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Wolters, EC Vrije Univ Amsterdam, Acad Ziekenhuis, Dept Neurol, POB 7057, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
E.C. Wolters et al., "Preclinical (premotor) Parkinson's disease", J NEUROL, 247, 2000, pp. 103-109

Abstract

Parkinson's disease (PD) is an idiopathic disease caused by necrosis and apoptosis of dopaminergic cells in the brainstem, which are probably inducedby oxidative stress. Current therapeutic strategies comprise symptomatic and restorative treatment. Neuroprotective treatment, however, is close to becoming reality. As neuroprotective therapy may be of particular benefit tothe preclinical and/or very early PD patients, identifying patients in theearly stages of the disease is a priority. Both [F-18]dopa positron emission tomography (PET) and [I-123]beta-CIT single photon emission computed tomography (SPECT) imaging may be useful tools in diagnosing early (preclinical) PD. As screening the whole population for preclinical PD is not realistic, one has to select subjects with a high risk for this disease. Ol-factorydisturbances, subtle neurocognitive dysfunction, visuomotor control abnormalities and, to a lesser degree, mood and personality disorders, have lately been suggested to precede or accompany early clinical motor hallmarks of PD. In an epidemiological study, 500 first-degree relatives of PD patients were assessed fur these signs and symptoms, and [I-123]P-CIT SPECT was performed on patients in the top 10% and the bottom 10% with regard to sense ofsmell. In this report, the study design and initial data from this ongoingstudy will be presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:51:56