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Titolo:
Mitochondrial dysfunction - A pathogenetic factor in Parkinson's disease
Autore:
Reichmann, H; Janetzky, B;
Indirizzi:
Tech Univ Dresden, Dept Neurol, D-01307 Dresden, Germany Tech Univ Dresden Dresden Germany D-01307 urol, D-01307 Dresden, Germany
Titolo Testata:
JOURNAL OF NEUROLOGY
, volume: 247, anno: 2000, supplemento:, 2
pagine: 63 - 68
SICI:
0340-5354(200004)247:<63:MD-APF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; COMPLEX-I DEFICIENCY; RESPIRATORY-CHAIN; SKELETAL-MUSCLE; SUBSTANTIA-NIGRA; POINT MUTATIONS; IRON CONTENT; BRAIN; DNA; DEFECT;
Keywords:
mitochondrial cytopathy; complex I; respiratory chain; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Reichmann, H Tech Univ Dresden, Dept Neurol, Fetscherstasse 74, D-01307 Dresden, Germany Tech Univ Dresden Fetscherstasse 74 Dresden Germany D-01307
Citazione:
H. Reichmann e B. Janetzky, "Mitochondrial dysfunction - A pathogenetic factor in Parkinson's disease", J NEUROL, 247, 2000, pp. 63-68

Abstract

The cause of Parkinson's disease is still unknown. Nonetheless, there are some generally accepted hypotheses with respect to the cascade of dopaminergic cell degeneration. One of the factors is a decrease in respiratory chain complex I activity. This enzyme abnormality is only found in substantia nigra pars compacta. It is not currently known whether this is due to a genetic abnormality of the nuclear or mitochondrial genome or to an exo- or endotoxin. To date, no specific abnormality of the mitochondrial genome has been detected, although ageing leads to deletions in up to 5% of all mitochondrial genome molecules in the brain. There is controversy whether this complex I defect is also detectable in muscle or blood cells. It is our conviction that the considerable overlap between blood cells from normal controls and patients with Parkinson's disease means that such measurements are not distinctive for the two conditions. A decrease in complex I activity in postmitotic cells may be one of the crucial factors for cell death.

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Documento generato il 28/03/20 alle ore 09:40:55