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Titolo:
The salt-inducible kinase, SIK, is induced by depolarization in brain
Autore:
Feldman, JD; Vician, L; Crispino, M; Hoe, W; Baudry, M; Herschman, HR;
Indirizzi:
Univ Calif Los Angeles, Ctr Hlth Sci, Inst Mol Biol, Los Angeles, CA 90095USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095USA Univ Calif Los Angeles, Ctr Hlth Sci, Dept Pediat, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Ctr Hlth Sci, Dept Biol Chem, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Ctr Hlth Sci, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Program, Los Angeles, CA 90089 USA Univ Naples Federico II, Dept Gen & Environm Physiol, Naples, Italy Univ Naples Federico II Naples Italy & Environm Physiol, Naples, Italy
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 6, volume: 74, anno: 2000,
pagine: 2227 - 2238
SICI:
0022-3042(200006)74:6<2227:TSKSII>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; IMMEDIATE-EARLY GENE; NERVE GROWTH-FACTOR; PC12 PHEOCHROMOCYTOMA CELLS; ELEMENT-BINDING PROTEIN; 3' UNTRANSLATED REGION; ADULT-RAT BRAIN; MESSENGER-RNA; SYNAPTOTAGMIN-IV; SEIZURE ACTIVITY;
Keywords:
serine protein kinase; gene expression; depolarization; kainic acid; PC12 cells; representational difference analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Herschman, HR Univ Calif Los Angeles, Ctr Hlth Sci, Inst Mol Biol, 611 Charles E Young Dr E, Los Angeles, CA 90095 USA Univ Calif Los Angeles 611 Charles E Young Dr E Los Angeles CA USA 90095
Citazione:
J.D. Feldman et al., "The salt-inducible kinase, SIK, is induced by depolarization in brain", J NEUROCHEM, 74(6), 2000, pp. 2227-2238

Abstract

Membrane depolarization of neurons is thought to lead to changes in gene expression that modulate neuronal plasticity, We used representational difference analysis to identify a group of cDNAs that are induced by membrane depolarization or by forskolin, but not by neurotrophins or growth factors, in PC12 pheochromocytoma cells. One of these genes, SIK ((s) over bar alt-(i) over bar nducible (k) over bar inase), is a member of the sucrose-nonfermenting 1 protein kinase/AMP-activated protein kinase protein kinase family that was also recently identified from the adrenal gland of rats treated with high-salt diets. SIK mRNA is induced up to eightfold in specific regionsof the hippocampus and cortex in rats, following systemic kainic acid administration and seizure induction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:42:12