Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Transtubular potassium concentration gradient (TTKG) and urine ammonium indifferential diagnosis of hypokalemia
Autore:
Joo, KW; Chang, SH; Lee, JG; Na, KY; Kim, YS; Ahn, C; Han, JS; Kim, S; Lee, JS;
Indirizzi:
Seoul Natl Univ Hosp, Clin Res Inst, Dept Internal Med, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea
Titolo Testata:
JOURNAL OF NEPHROLOGY
fascicolo: 2, volume: 13, anno: 2000,
pagine: 120 - 125
SICI:
1121-8428(200003/04)13:2<120:TPCG(A>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OSMOLAL GAP; ANION GAP; EXCRETION; EVALUATE;
Keywords:
hypokalemia; TTKG; urine ammonium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Han, JS Seoul Natl Univ, Coll Med, Chongno Gu, 28 Yongon Dong, Seoul 110744, SouthKorea Seoul Natl Univ 28 Yongon Dong Seoul South Korea 110744 outhKorea
Citazione:
K.W. Joo et al., "Transtubular potassium concentration gradient (TTKG) and urine ammonium indifferential diagnosis of hypokalemia", J NEPHROL, 13(2), 2000, pp. 120-125

Abstract

Background: Hypokalemia is a common and sometimes serious clinical problem, whose etiological diagnosis can frequently be based on the patient's history and the clinical setting. Measurement of urinary indices such as excretory rate of K+, random urine K+ concentrations and blood acid-base parameters have been employed in the pathophysiological diagnosis, though with somepitfalls. Methods: To investigate the diagnostic usefulness of the transtubular potassium concentration gradient (TTKG) and urine ammonium in the differentiation of hypokalemia, we measured serum K+ and osmolality, random urine electrolytes, osmolality and ammonium, the urinary [Na]/[K] ratio (U-Na/K), plasma aldosterone and TTKG in 7 patients with diarrhea, 6 with vomiting, 7 withmineralocorticoid excess, 6 with diuretic usage, and compared them with those of 7 overnight fasted and acid-loaded healthy volunteers. Results: The urine K+ concentrations did not reflect urinary loss of potassium according to the subjects hydration status. U-Na/k in the hypokalemic patients with mineralocorticoid excess (1.4 +/- 0.5) was lower than in normal subjects (2.3 +/- 0.4) (p < 0,05). TTKG was higher in hypokalemic patients with mineralocorticoid excess (13.3 +/- 4.4) and diuretic usage (8.6 +/-1.3) and lower in those with diarrhea (1.6 +/- 0.3) than in the normal controls (5.0 +/- 0.7) (p < 0.5). TTKG in the patients with vomiting (3.5 +/- 0.6) was the same as in normal controls. TTKG was stronger correlated with the plasma aldosterone levels in the hypokalemic patients due to renal potassium loss. Urine ammonium concentrations of the acid-loaded normal subjects (73.3 +/- 5.0 mEq/L), patients with diarrhea (74.4 +/- 2.0 mEq/L) and patients with mineralocorticoid excess (68.7 +/- 6.9 mEq/L) were higher than in overnight-fasted normal subjects (31.3 +/- 4.9 mEq/L). Conclusion: TTKG and random urine ammonium were useful in the pathophysiological differential diagnosis of hypokalemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:01:22