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Titolo:
Postnatal lethality of P-cadherin/desmoglein 3 double knockout mice: Demonstration of a cooperative effect of these cell adhesion molecules in tissuehomeostasis of stratified squamous epithelia
Autore:
Lenox, JM; Koch, PJ; Mahoney, MG; Lieberman, M; Stanley, JR; Radice, GL;
Indirizzi:
Univ Penn, Ctr Res Reprod & Womens Hlth, Sch Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Sch Med, Philadelphia, PA 19104 USA Univ Penn, Dept Dermatol, Sch Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Sch Med, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 5, volume: 114, anno: 2000,
pagine: 948 - 952
SICI:
0022-202X(200005)114:5<948:PLOP3D>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-CADHERIN; DESMOSOMAL CADHERINS; MOUSE; EXPRESSION; MORPHOGENESIS; GENE; KERATINOCYTES; PEMPHIGUS; EMBRYOS; MUTANT;
Keywords:
adherens junction; desmosome; oral mucosa; pemphigus vulgaris;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Radice, GL Univ Penn, Ctr Res Reprod & Womens Hlth, Sch Med, 1355 Biomed Res Bldg 2,421 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn 1355 Biomed Res Bldg 2,421 Curie Blvd Philadelphia PA USA 19104
Citazione:
J.M. Lenox et al., "Postnatal lethality of P-cadherin/desmoglein 3 double knockout mice: Demonstration of a cooperative effect of these cell adhesion molecules in tissuehomeostasis of stratified squamous epithelia", J INVES DER, 114(5), 2000, pp. 948-952

Abstract

To investigate the cooperativity of different cell adhesion molecules in maintaining the structural integrity of the epidermis, we have generated mice deficient for both a classical cadherin, P-cadherin, and a desmosomal cadherin, desmoglein 3. In epithelial cells, P-cadherin is localized to the adherens junction, whereas desmoglein 3 is found in desmosomes. Previous studies have shown that these two junctional complexes are important for keratinocyte cell-cell adhesion. Both P-cadherin and desmoglein 3 expression are restricted to the basal and most immediate suprabasal cells of the epidermis, whereas both proteins are found throughout the oral mucosal epithelium. Although P-cadherin mutant mice have no apparent defect in epithelial cell adhesion, the desmoglein 3 mutant phenotype resembles that of patients withthe autoimmune disease pemphigus vulgaris, in that the mice develop spontaneous mucous membrane blisters and trauma-induced skin blisters. The oral lesions in DSG3-/- mice reduce their food intake, resulting in a runted phenotype; however, most animals recover and live past weaning age. In contrast, animals mutant for both P-cadherin and desmoglein 3 die before weaning. The majority of the double mutant animals die around 1 wk after birth, apparently due to malnutrition. These studies suggest that loss of P-cadherin leads to a more severe desmoglein 3 mutant phenotype in the double knockout mice. This is the first in vivo evidence of possible synergism between a classical and desmosomal cadherin.

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Documento generato il 19/09/20 alle ore 18:18:19