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Titolo:
Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging
Autore:
Prata, MIM; Santos, AC; Geraldes, CFGC; de Lima, JJP;
Indirizzi:
Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, Coimbra, Portugal Univ Coimbra Coimbra Portugal & Tecnol, Dept Bioquim, Coimbra, Portugal Univ Coimbra, Fac Med, Serv Biofis & Biomatemat, Coimbra, Portugal Univ Coimbra Coimbra Portugal rv Biofis & Biomatemat, Coimbra, Portugal Univ Coimbra, Ctr Neurociencias, Coimbra, Portugal Univ Coimbra Coimbra Portugal bra, Ctr Neurociencias, Coimbra, Portugal
Titolo Testata:
JOURNAL OF INORGANIC BIOCHEMISTRY
fascicolo: 1-4, volume: 79, anno: 2000,
pagine: 359 - 363
SICI:
0162-0134(200004)79:1-4<359:SAIVSO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEXES; GALLIUM(III); GA-67; NMR; BIODISTRIBUTION; TRANSFERRIN; STABILITY; LIGANDS; BINDING; IN-111;
Keywords:
gallium; triazamacrocycle; phosphonate; structure; biodistribution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Geraldes, CFGC Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, Coimbra,Portugal Univ Coimbra Coimbra Portugal Bioquim, Coimbra, Portugal
Citazione:
M.I.M. Prata et al., "Structural and in vivo studies of metal chelates of Ga(III) relevant to biomedical imaging", J INORG BIO, 79(1-4), 2000, pp. 359-363

Abstract

The solution chemistry and structure of the complex of the triazamacrocyclic ligand NOTP (1,4,7-triazacyclononane-1,4,7-tris(methylenephosphonate)) with Ga3+ in D2O have been investigated by H-1, Ga-71 and P-31 NMR spectroscopy. These NMR results show the presence of a 1:1 Ga(NOTP)(3-) complex, with a highly symmetrical, pseudo-octahedral geometry, possibly with a C-3 axis. The H-1 spectrum shows that the triazamacrocyclic chelate ring is very rigid, with all the ring protons non-equivalent. The complex is stable in aqueous solution in a wide pH range. Its high thermodynamic stability agrees well with previous results from biodistribution and gamma imaging studies in Wistar rats with Ga-67(3+) chelates of triaza macrocyclic ligands, which showed that the neutral chelates Ga-67(NOTA) (where NOTA is 1,4,7-triazacyclononane-1,4,7-triacetate) and Ga-67(NOTPME) (where NOTPME is 1,4,7-triazacyclononane-1,4,7-tris( methylenephosphonate monoethylester)) have similar in vivo behaviour, with high stability and rapid renal excretion, but the high negatively charged Ga-67( NOTP)(3-) has a considerably slower kidney uptake and elimination. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:28:29