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Titolo:
Alterations in skeletal muscle morphology in glucose-toelrant elderly hypertensive men: relationship to development of hypertension and heart rate
Autore:
Hedman, A; Reneland, R; Lithell, HO;
Indirizzi:
Uppsala Univ, Geriatr Unit, Dept Publ Hlth & Caring Sci, S-71525 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-71525 Caring Sci, S-71525 Uppsala, Sweden
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 5, volume: 18, anno: 2000,
pagine: 559 - 565
SICI:
0263-6352(200005)18:5<559:AISMMI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY RAREFACTION; INSULIN-RESISTANCE; FIBER COMPOSITION; BORDERLINE HYPERTENSION; BLOOD-PRESSURE; CIRCULATION; METABOLISM; EXERCISE; DENSITY; OBESITY;
Keywords:
capillary supply; heart rate; hypertension; muscle fibre distribution; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Hedman, A Uppsala Univ, Geriatr Unit, Dept Publ Hlth & Caring Sci, Kalsangsgrand 10D,POB 609, S-71525 Uppsala, Sweden Uppsala Univ Kalsangsgrand 10D,POB 609 Uppsala Sweden S-71525 n
Citazione:
A. Hedman et al., "Alterations in skeletal muscle morphology in glucose-toelrant elderly hypertensive men: relationship to development of hypertension and heart rate", J HYPERTENS, 18(5), 2000, pp. 559-565

Abstract

Objective To compare the muscle morphology in hypertensive subjects with that in controls and to test the hypothesis of a relation between heart rate, development of hypertension and muscle morphology that is independent of glucose intolerance. Patients and methods We studied 43 glucose-tolerant, untreated hypertensive subjects and 113 healthy controls in a longitudinal cohort of 70-year-oldmen. Metabolic status (oral glucose tolerance test and euglycemic, hyperinsulinaemic clamp test), muscle fibre distribution (myosin ATPase staining) and capillary supply (amylase-PAS method) were evaluated, Blood pressure and heart rate data were available from both ages 50 and 70 years. Results Hypertensive subjects had a significantly smaller mean number of capillaries per fibre than controls (1.53 versus 1.64; P=0.04). In hypertensive subjects, the proportions of type I and type II fibres were correlated to mean arterial pressure (r= -0.56 and r= 0.52, respectively, P< 0.05 for both), The increase in mean arterial pressure over 20 years was closely correlated to capillary density in mm(2) (r= -0.62; P< 0.0001). Capillary supply was inversely related to resting heart rate both at ages 50 and 70 years. Conclusions Skeletal muscle of glucose tolerant hypertensive subjects showed a lower capillary supply than that of controls, This capillary rarefaction was correlated to increase in mean arterial pressure over two decades and to supine heart rate. This is compatible with the suggestion that higher sympathetic drive might generate structural alterations in muscle capillarization, I Hypertens 2000, 18:559-565 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:26:15