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Titolo:
Review and management of clozapine side effects
Autore:
Miller, DD;
Indirizzi:
Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 , Dept Psychiat, Iowa City, IA 52242 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
, volume: 61, anno: 2000, supplemento:, 8
pagine: 14 - 17
SICI:
0160-6689(2000)61:<14:RAMOCS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AGRANULOCYTOSIS; ANTIPSYCHOTIC AGENT; SCHIZOPHRENIC-PATIENTS; TARDIVE-DYSKINESIA; WEIGHT-GAIN; FLOW-RATE; SEDATION; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, DD Univ Iowa, Dept Psychiat, 200 Hawkins Dr,2887 JPP, Iowa City, IA 52242 USA Univ Iowa 200 Hawkins Dr,2887 JPP Iowa City IA USA 52242 42 USA
Citazione:
D.D. Miller, "Review and management of clozapine side effects", J CLIN PSY, 61, 2000, pp. 14-17

Abstract

Clozapine has demonstrated superior efficacy in relieving positive and negative symptoms in treatment-resistant schizophrenic patients; unlike other antipsychotics, it causes minimal extrapyramidal side effects (EPS)and has little effect on serum prolactin. Despite these benefits. the use of clozapine has been limited because of infrequent but serious side effects, the most notable being agranulocytosis. In recent years, however, mandatory bloodmonitoring has significantly reduced both the incidence of agranulocytosisand its associated mortality. The occurrence of seizures appears to be dose-related and can generally be managed by reduction in clozapine dosage. Less serious and more common side effects of clozapine including sedation, hypersalivation, tachycardia, hypotension, hypertension. weight gain, constipation, urinary incontinence, and fever can often be managed medically and are generally tolerated by the patient. Appropriate management of clozapine side effects facilitates a maximization of the benefits of clozapine treatment, and physicians and patients alike should be aware that there is a range of benefits to clozapine use that is wider than its risks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:11:43