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Titolo:
Effects of intracardiac radiofrequency current application on coronary artery vessels in young pigs
Autore:
Bokenkamp, R; Wibbelt, G; Sturm, M; Windhagen-Mahnert, B; Bertram, H; Hausdorf, G; Paul, T;
Indirizzi:
Hannover Med Sch, Dept Pediat Cardiol, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 iol, D-30625 Hannover, Germany Hannover Med Sch, Dept Cardiol, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 iol, D-30625 Hannover, Germany
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 5, volume: 11, anno: 2000,
pagine: 565 - 571
SICI:
1045-3873(200005)11:5<565:EOIRCA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATHETER ABLATION; ACCESSORY PATHWAYS; CHILDREN; ENERGY; ARRHYTHMIAS; MYOCARDIUM; OCCLUSION;
Keywords:
radiofrequency catheter ablation; coronary artery; children; intravascular avascular ultrasound;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Bokenkamp, R Hannover Med Sch, Dept Pediat Cardiol, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 Hannover, Germany
Citazione:
R. Bokenkamp et al., "Effects of intracardiac radiofrequency current application on coronary artery vessels in young pigs", J CARD ELEC, 11(5), 2000, pp. 565-571

Abstract

Radiofrequency Current Lesions in Young Pigs. Introduction: Radiofrequencycurrent is widely used in children to ablate accessory AV pathways. Previous data in a pig model demonstrated coronary artery obstruction adjacent toradiofrequency current lesions 48 hours and 6 months after energy delivery. In the present study, the long-term effects (>6 months) of radiofrequencycurrent application on coronary artery vessels in young pigs are assessed. Methods and Results: Radiofrequency current (500 kHz) was delivered over 30 seconds in ten piglets (mean body weight 12.8 kg) using a steerable 6-French catheter with a 4-mm thermistor tip electrode (target temperature 75 degrees C). Lesions were created under fluoroscopic and electrocardiographic guidance at the lateral right atrial (RA) wall above the tricuspid valve orifice, and at the lateral left atrial and left ventricular wall adjacent tothe mitral valve orifice, Selective coronary angiography and intravascularultrasound (IVUS) studies were performed 3, 6, 9, and 12 months after energy application. After 12 months, the lesions were studied pathohistologically. All lesions consisted of compact fibrous tissue. RA lesions extended tothe adjacent right coronary artery and led to coronary artery involvement with increased fibrous tissue in the adventitia and media and intimal thickening in three animals. Coronary arterial narrowing was documented by IVUS during follow-up in all three cases 9 months after energy application. Angiography failed to demonstrate coronary pathology in any of the three animals. Conclusion: The risk of late coronary artery lesions must be considered when catheter ablation at the RA wall is planned in children with free-wall accessory AV pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 02:17:27