Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dynamic subcellular distribution of the DAZL protein is confined to primate male germ cells
Autore:
Ruggiu, M; Saunders, PTK; Cooke, HJ;
Indirizzi:
Western Gen Hosp, Chromosome Biol Sect, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland MRC, Reprod Biol Unit, Edinburgh, Midlothian, Scotland MRC Edinburgh Midlothian Scotland Unit, Edinburgh, Midlothian, Scotland
Titolo Testata:
JOURNAL OF ANDROLOGY
fascicolo: 3, volume: 21, anno: 2000,
pagine: 470 - 477
SICI:
0196-3635(200005/06)21:3<470:DSDOTD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
Y-CHROMOSOME; MESSENGER-RNA; AUTOSOMAL GENE; AZOOSPERMIA; SPERMATOGENESIS; TRANSCRIPTION; LOCALIZATION; SPECIFICITY; DROSOPHILA; HOMOLOG;
Keywords:
DAZ; azoospermia; Y chromosome; RNA-binding proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Cooke, HJ Western Gen Hosp, Chromosome Biol Sect, MRC, Human Genet Unit, Crewe Rd, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Crewe Rd Edinburgh Midlothian Scotland EH4 2XU
Citazione:
M. Ruggiu et al., "Dynamic subcellular distribution of the DAZL protein is confined to primate male germ cells", J ANDROLOGY, 21(3), 2000, pp. 470-477

Abstract

We have examined the location of the DAZL protein in fetal and adult rodents and human specimens and found that there is a shift from a predominantlynuclear to a predominantly cytoplasmic distribution of the protein in human testis, In rat testis and human ovary, however, the protein is predominantly, if not exclusively, cytoplasmic throughout germ cell development. One possible explanation for this could be that the DAZ protein is responsible for the nuclear localization of DAZL in human males. We have tested this hypothesis by examining the testis of marmosets, which lack the Daz genes andhave found that the DAZL protein is both nuclear and cytoplasmic in spermatogonia, and by analyzing testis sections from DAZ-defeted patients in whomthe cytoplasmic location of DAZL is evident in remaining germ cells. Transfection experiments indicate that the differences in DAZL expression between rodents and humans are not caused by the amino acid differences between the 2 proteins, and that DAZL is a cytoplasmic protein per se. Variations inlocation seem to be independent of the presence of the DAZ protein are species specific and. as in Drosophila, may not have great functional significance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 21:58:56