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Titolo:
First experience with I-123-alpha-methyl-tyrosine SPECT in the 3-D radiation treatment planning of brain gliomas
Autore:
Grosu, AL; Weber, W; Feldmann, HJ; Wuttke, B; Bartenstien, P; Gross, MW; Lumenta, C; Schwaiger, M; Molls, M;
Indirizzi:
Tech Univ Munich, Klinikum Rechts Isar, Klin & Poliklin Strahlentherapie &Radiol, D-81675 Munich, Germany Tech Univ Munich Munich Germany D-81675 &Radiol, D-81675 Munich, Germany Tech Univ Munich, Klinikum Rechts Isar, Nukl Med Klin & Poliklin, D-81675 Munich, Germany Tech Univ Munich Munich Germany D-81675 oliklin, D-81675 Munich, Germany Stadt Krankenhaus Munchen Bogenhausen, Neurochirurg Klin, D-8000 Munich, Germany Stadt Krankenhaus Munchen Bogenhausen Munich Germany D-8000 ich, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 2, volume: 47, anno: 2000,
pagine: 517 - 526
SICI:
0360-3016(20000501)47:2<517:FEWISI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ALPHA-METHYL TYROSINE; AMINO-ACID-TRANSPORT; MALIGNANT GLIOMAS; IODINE-123-ALPHA-METHYL TYROSINE; L-3-IODO-ALPHA-METHYL TYROSINE; COMPUTED-TOMOGRAPHY; INITIAL MANAGEMENT; GLIAL NEOPLASMS; METHIONINE PET;
Keywords:
I-123-alpha-methyl-tyrosine; SPECT; MRI; radiotherapy; malignant glioma; 3D treatment planning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Feldmann, HJ Tech Univ Munich, Klinikum Rechts Isar, Klin & Poliklin Strahlentherapie &Radiol, Ismaninger Str 22, D-81675 Munich, Germany Tech Univ Munich Ismaninger Str 22 Munich Germany D-81675 ny
Citazione:
A.L. Grosu et al., "First experience with I-123-alpha-methyl-tyrosine SPECT in the 3-D radiation treatment planning of brain gliomas", INT J RAD O, 47(2), 2000, pp. 517-526

Abstract

Purpose: This study compares the results of iodine-123-alpha-methyl-tyrosine single photon computed emission tomography (IMT-SPECT) with magnetic resonance imaging (MRI) in tumor volume definition of brain gliomas. Furthermore, it evaluates the influences of the information provided from IMT-SPECT for three-dimensional (3D) conformal treatment planning. Methods and Materials: In 30 patients with nonresected, histologically proven brain gliomas (glioblastoma-13 patients, astrocytoma Grade III-12 patients, astrocytoma Grade II-3 patients, oligodendroglioma Grade III-1 patient, oligodendroglioma Grade II-1 patient), IMT-SPECT and MRI were performed pretherapeutically in the same week. A special software system allowed the coregistration of the IMT-SPECT and MRI data. The gross tumor volume (GTV) defined on the IMT-SPECT/T2-MRI fusion images (GTV-IMT/T2) was compared withthe GTV-T2, defined on the T2-MRI alone. On the IMT-SPECT/T1Gd-MRI overlays, the volume of the IMT tumor uptake (GTV-IMT) was compared with the volume of the gadolinium (Gd) enhancement (GTV-T1Gd). The initial planning target volume (PTV) and the boost volume (BV) outlined on the IMT-SPECT/T2-MRI co-images were analyzed comparatively to the PTV and BV delineated using theT2-MRI alone. Results: In all 30 patients a higher IMT uptake of tumor areas, compared to the normal brain tissue was observed. Mean GTV-IMT, mean GTV-T2, and meanGTV-T1Gd were 43, 82, and 16 cm(3), respectively. IMT tumor uptake outsidethe contrast enhancement regions was observed in all patients. Mean relative increase of tumor volume defined on the fusion images, GTV-IMT/T1Gd versus GTV-T1Gd alone was 78%. IMT tumor uptake areas outside the GTV-T2 were registered in 7 patients (23%). In these patients, the mean increase GTV-IMT/T2 was 33% higher than GTV-T2, defined according to the T2-MRI data alone. The additional information provided by IMT-SPECT modified minimally the initial PTV (mean relative increase PTV-IMT/T2 versus PTV-T2, 5%) but significantly the BV (mean relative increase BV-IMT/T2 versus BV-T2, 37%). Conclusion: In a significant number of patients, the IMT-SPECT investigation improves tumor detection and delineation in the planning process. This has important consequences in the 3D conformal treatment planning, especially in the delineation of BV and in dose escalation studies. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/21 alle ore 05:21:00