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Titolo:
Salmonella typhimurium-induced reactivation of latent HIV-1 in promonocytic U1 cells is inhibited by Trovafloxacin
Autore:
Gollapudi, S; Gupta, S; Thadepalli, H;
Indirizzi:
Univ Calif Irvine, Dept Med, Div Basic & Clin Immunol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 Clin Immunol, Irvine, CA 92697 USA Charles R Drew Univ Med & Sci, Div Geriatr & Gerontol, Los Angeles, CA 90059 USA Charles R Drew Univ Med & Sci Los Angeles CA USA 90059 eles, CA 90059 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 6, volume: 5, anno: 2000,
pagine: 615 - 618
SICI:
1107-3756(200006)5:6<615:STROLH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; FACTOR-ALPHA PRODUCTION; BACTEROIDES-FRAGILIS; GENE-EXPRESSION; INFECTION; TYPE-1; ACTIVATION; MACROPHAGE;
Keywords:
Trovafloxacin; Salmonella; latent HIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Gollapudi, S Univ Calif Irvine, Dept Med, Div Basic & Clin Immunol, Med Sci Bldg 1 RoomC240, Irvine, CA 92697 USA Univ Calif Irvine Med Sci Bldg 1 Room C240 Irvine CA USA 92697
Citazione:
S. Gollapudi et al., "Salmonella typhimurium-induced reactivation of latent HIV-1 in promonocytic U1 cells is inhibited by Trovafloxacin", INT J MOL M, 5(6), 2000, pp. 615-618

Abstract

We have previously reported that virulent Salmonella typhimurium induces replication of latent HIV-1 in U1 cells, via activation of tumor necrosis factor-alpha (TNF-alpha) production. In the present study, we show that Trovafloxacin, a new quinolone antibiotic, inhibits S. typhimurium-induced TNF-alpha production and HIV-1 replication. In addition, Trovafloxacin inhibits TNF-alpha-induced reactivation of latent HIV-1 in U1 cells. The concentrations of Trovafloxacin that inhibited HIV-1 replication are comparable to theplasma and tissue levels achieved by therapeutic dosage used in the treatment of bacterial infections. Therefore, Trovafloxacin is a potential candidate for adjunct therapy in HIV-1 infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:25:51