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Titolo:
Monotypic epithelioid angiomyolipoma of the liver
Autore:
Yamasaki, S; Tanaka, S; Fujii, H; Matsumoto, T; Okuda, C; Watanabe, G; Suda, K;
Indirizzi:
Juntendo Univ, Sch Med, Dept Pathol 1, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 hol 1, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ, Sch Med, Dept Pathol 2, Tokyo 1138421, Japan Juntendo UnivTokyo Japan 1138421 d, Dept Pathol 2, Tokyo 1138421, Japan Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan Toranomon Gen Hosp Tokyo Japan omon Gen Hosp, Dept Pathol, Tokyo, Japan Toranomon Gen Hosp, Dept Gastroenterol, Tokyo, Japan Toranomon Gen Hosp Tokyo Japan n Hosp, Dept Gastroenterol, Tokyo, Japan Toranomon Gen Hosp, Dept Digest Surg, Tokyo, Japan Toranomon Gen Hosp Tokyo Japan Gen Hosp, Dept Digest Surg, Tokyo, Japan
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 5, volume: 36, anno: 2000,
pagine: 451 - 456
SICI:
0309-0167(200005)36:5<451:MEAOTL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL SUGAR TUMOR; HEPATIC ANGIOMYOLIPOMA; TUBEROUS SCLEROSIS; SMOOTH-MUSCLE; KIDNEY; HMB-45; HETEROZYGOSITY; FAMILY; REGION; TSC2;
Keywords:
angiomyolipoma; liver; epithelioid cells; HMB45; loss of heterozygosity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Yamasaki, S Juntendo Univ, Sch Med, Dept Pathol 1, Bunkyo Ku, Hongo 2-1-1,Tokyo 1138421, Japan Juntendo Univ Hongo 2-1-1 Tokyo Japan 1138421 1138421, Japan
Citazione:
S. Yamasaki et al., "Monotypic epithelioid angiomyolipoma of the liver", HISTOPATHOL, 36(5), 2000, pp. 451-456

Abstract

Aims: Monotypic epithelioid angiomyolipoma is a recently recognized renal tumour, which is composed purely of epithelioid cells coexpressing markers of both smooth muscle differentiation and melanogenesis (HMB45). We report here the first case of monotypic epithelioid angiomyolipoma arising in the liver. Case details: A 30-year-old woman without tuberous sclerosis complex (TSC)was incidentally found to have a hepatic mass by ultrasonography. Grossly,the resected tumour showed a nodule-in-nodule appearance, with large areasof haemorrhagic necrosis. Microscopically, the tumour was composed of pleomorphic epithelioid cells with clear, eosinophilic cytoplasm. Neither adipocytes nor abnormal vessels were recognized in the tumour. Immunohistochemically, the tumour cells were strongly positive for HMB45 and S100 protein, focally positive for desmin, vimentin and smooth muscle actin, and negative for epithelial markers (cytokeratins, EMA). Ultrastructural analysis showednumerous dense granules with some striated ones resembling melanosomes, myofilaments and pinocytic vesicles in the cytoplasm. Molecular analysis showed no allelic loss of the TSC2 region or 12 other chromosomal regions. The patient is free of disease over 1 year after the operation. Conclusion: We consider that this hepatic tumour is closely related to angiomyolipoma, and a counterpart of renal monotypic epithelioid angiomyolipoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:12:13