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Titolo:
Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbtdomains, structurally belonging to the Polycomb group of genes
Autore:
Usui, H; Ichikawa, T; Kobayashi, K; Kumanishi, T;
Indirizzi:
Niigata Univ, Brain Res Inst, Dept Mol Neuropathol, Niigata 9518585, JapanNiigata Univ Niigata Japan 9518585 l Neuropathol, Niigata 9518585, Japan
Titolo Testata:
GENE
fascicolo: 1-2, volume: 248, anno: 2000,
pagine: 127 - 135
SICI:
0378-1119(20000502)248:1-2<127:COANMG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA SEX COMB; MIDLEG SCM; ZINC-FINGER; PROTEIN; IDENTIFICATION; ENCODES; HOMOLOG; DEFECTS; MICE;
Keywords:
cDNA; chromosomal localization; exon-intron organization; mbt repeats; SPM domain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Usui, H Niigata Univ, Brain Res Inst, Dept Mol Neuropathol, 1-757 Asahimachi, Niigata 9518585, Japan Niigata Univ 1-757 Asahimachi Niigata Japan 9518585 518585, Japan
Citazione:
H. Usui et al., "Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbtdomains, structurally belonging to the Polycomb group of genes", GENE, 248(1-2), 2000, pp. 127-135

Abstract

A novel cDNA clone encoding a protein structurally related to the transcriptional repressor Polycomb group (PcG) proteins, which regulate homeotic genes and others, was isolated from mouse and rat brain. The coding protein contained the SPM domain and mbt repeats, both of which are characteristic of the PcG proteins, and showed significant similarity in amino acid sequence to the Drosophila Sex comb on midleg (Scm) protein. Since this novel protein contains the mbt repeats in four tandem copies, we designated this murine gene as Sfmbt for Scm-related gene containing four mbt domains. Cloning and characterization of the mouse Sfmbt gene revealed that the coding sequence comprised 20 exons, dispersed along approximately 40 kb, and mapped to the proximal part of Chromosome 14. Northern blot analysis showed that the Sfmbt mRNAs were expressed most abundantly in the adult testis, and less intensively in all other tissues examined. (C) 2000 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:43:06