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Titolo:
Alzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degreeof dementia
Autore:
Thal, DR; Holzer, M; Rub, U; Waldmann, G; Gunzel, S; Zedlick, D; Schober, R;
Indirizzi:
Univ Leipzig, Inst Pathol, Dept Neuropathol, D-04103 Leipzig, Germany UnivLeipzig Leipzig Germany D-04103 uropathol, D-04103 Leipzig, Germany Univ Leipzig, Dept Psychiat, D-04103 Leipzig, Germany Univ Leipzig Leipzig Germany D-04103 Psychiat, D-04103 Leipzig, Germany Univ Frankfurt, Dept Anat, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 nat, D-60590 Frankfurt, Germany Univ Leipzig, Paul Flechsig Inst Brain Res, Dept Neuroanat, D-04109 Leipzig, Germany Univ Leipzig Leipzig Germany D-04109 Neuroanat, D-04109 Leipzig, Germany
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 163, anno: 2000,
pagine: 98 - 110
SICI:
0014-4886(200005)163:1<98:ATITPP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED HELICAL FILAMENTS; AMYLOID-BETA-PEPTIDE; NEUROFIBRILLARY TANGLES; ENTORHINAL CORTEX; DENTATE GYRUS; PROTEIN-TAU; HUMAN-BRAIN; NEUROPIL THREADS; SENILE PLAQUES; SYNAPSE LOSS;
Keywords:
Alzheimer's disease; PHF-tau staging; hippocampus; perforant path; clinical dementia rating;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Thal, DR Univ Leipzig, Inst Pathol, Dept Neuropathol, D-04103 Leipzig, Germany Univ Leipzig Leipzig Germany D-04103 , D-04103 Leipzig, Germany
Citazione:
D.R. Thal et al., "Alzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degreeof dementia", EXP NEUROL, 163(1), 2000, pp. 98-110

Abstract

Abnormal phosphorylation of the tau-protein is regarded as a crucial step in the formation of neurofibrillary tangles in the neuronal cell body and neuropil threads in dendrites. We studied the effects of tau-pathology on the clinical expression of dementia in 106 autopsy cases in the entorhinal region, the hippocampal stratum oriens, the stratum radiatum, and the perforant path target zone. The first cytoskeletal lesions were located in the perikarya and dendrites of the pre-alpha cells of the transentorhinal and entorhinal region. Next, abnormally phosphorylated tau-protein (PHF-tau) was found in the neuropil of the CA1-subiculum region. Thereafter, the stratum radiatum and stratum oriens began to be involved in PHF-tau pathology in Braak stage II. In the Braak stages TV and V, the stratum radiatum was completely involved, the stratum oriens increasingly so. Beginning in Braak stage III, we noted cases having PHF-tau pathology in the perforant path target zone of the outer molecular layer of the dentate gyrus. The increase of this pathology with ever greater involvement on the part of the entorhino-hippocampal circuit correlated significantly not only with the Braak stages and with the neurochemically determined hippocampal content of PHF-tau but also with the degree of dementia as defined by the clinical dementia rating (CDR) scale. The affection of the stratum oriens in combination with PHF-tau pathology in the stratum radiatum and in the outer molecular layer of the dentate gyrus was encountered almost exclusively in demented individuals (CDR). These results indicate that axonal PHF-tau pathology in hippocampal pathways presumably is critical for the clinical expression of dementia and may constitute an anatomical substrate of clinically verifiable memory dysfunction in Alzheimer's disease. (C) 2000 Academic Press.

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Documento generato il 31/03/20 alle ore 09:14:31