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Titolo:
Changes in cerebral blood flow and distribution associated with acute increases in plasma sodium and osmolality of chronic hyponatremic rats
Autore:
Adler, S; Verbalis, JG; Meyers, S; Simplaceanu, E; Williams, DS;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 ept Med, Pittsburgh, PA 15213 USA Georgetown Univ, Sch Med, Dept Med, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 ept Med, Washington, DC 20007 USA Carnegie Mellon Univ, NMR Ctr Biomed Res, Pittsburgh, PA 15213 USA Carnegie Mellon Univ Pittsburgh PA USA 15213 es, Pittsburgh, PA 15213 USA
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 163, anno: 2000,
pagine: 63 - 71
SICI:
0014-4886(200005)163:1<63:CICBFA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-BARRIER PERMEABILITY; COMPLEMENT ACTIVATION; ARTERIAL WATER; OLIGODENDROCYTES; ABSENCE; HYPERCAPNIA; ANTIBODIES; PERFUSION; SEQUELAE; MYELIN;
Keywords:
cerebral perfusion; magnetic resonance flow imaging; demyelination; blood-brain barrier;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Adler, S Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA UnivPittsburgh Pittsburgh PA USA 15213 Pittsburgh, PA 15213 USA
Citazione:
S. Adler et al., "Changes in cerebral blood flow and distribution associated with acute increases in plasma sodium and osmolality of chronic hyponatremic rats", EXP NEUROL, 163(1), 2000, pp. 63-71

Abstract

The cause of the osmotic demyelination syndrome that follows too rapid correction of chronic hyponatremia (CHN) is unknown. Recently, we reported in CHN rats an association between blood-brain barrier (BBB) disruption occurring as early as 3 h into correction and subsequent demyelination. Given thechanges in brain water and blood volume which occur during correction of CHN, we hypothesized that the same correction protocol that causes demyelination might alter cerebral blood how (CBF) during correction, thereby possibly contributing to BBB disruption and demyelination. Ten CHN rats were given hypertonic sodium intraperitoneally and its effect on CBF was continuously monitored for 3 h by magnetic resonance how imaging. Over the subsequent 3 h, plasma sodium rose from 110.8 to 127.6 mEq/liter (P < 0.001) but neither mean arterial blood pressure nor arterial CO2 tension changed significantly. By 30 min, CBF increased by 50% in cortical and subcortical areas (P <0.001) and remained elevated for the next 60 min. After 2 h, cortical flowwas no longer elevated significantly and by 3 h it had returned to controlvalues. Subcortical flow, however, significantly exceeded control values throughout the 3 h so that after 2 h the ratio of cortical to subcortical blood flow had fallen from 1.17 to 0.91 (P < 0.05). Although the mechanism bywhich increased plasma sodium and osmolality alters CBF is uncertain, the results suggest that changes in CBF may be part of a cascade of cerebrovascular disturbances including endothelial or parenchymal damage, mechanical events, metabolic disturbances, or cytokine release which eventually lead toBBB disruption and subsequent demyelination. (C) 2000 Academic Press.

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Documento generato il 22/09/20 alle ore 08:03:49