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Titolo:
Sequential scintigraphic strategy for the differentiation of brain tumours
Autore:
Matheja, P; Rickert, C; Weckesser, M; Palkovic, S; Lottgen, J; Riemann, B; Kopka, K; Kuwert, T; Wassmann, H; Paulus, W; Schober, O;
Indirizzi:
Univ Munster, Dept Nucl Med, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 pt Nucl Med, D-4400 Munster, Germany Univ Munster, Dept Neurosurg, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 t Neurosurg, D-4400 Munster, Germany Univ Munster, Inst Neuropathol, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 Neuropathol, D-4400 Munster, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 5, volume: 27, anno: 2000,
pagine: 550 - 558
SICI:
0340-6997(200005)27:5<550:SSSFTD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ALPHA-METHYL TYROSINE; F-18 FLUORODEOXYGLUCOSE PET; COMPUTED-TOMOGRAPHY; IODINE-123-ALPHA-METHYL TYROSINE; L-3-IODO-ALPHA-METHYL TYROSINE; INTRACRANIAL TUMORS; CEREBRAL GLIOMAS; PRIMARY LYMPHOMA; METHIONINE PET;
Keywords:
brain tumour; single-photon emission tomography; iodine-123 alpha-methyltyrosine; thallium-201;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Matheja, P WWU Munster, Dept Nucl Med, Albert Schweitzer Str 33, D-48129 Munster, Germany WWU Munster Albert Schweitzer Str 33 Munster Germany D-48129 y
Citazione:
P. Matheja et al., "Sequential scintigraphic strategy for the differentiation of brain tumours", EUR J NUCL, 27(5), 2000, pp. 550-558

Abstract

Both thallium-201 and iodine-123 alpha-methyltyrosine (I-123-IMT) have been shown to be useful in the diagnostic evaluation of brain rumours. The aimof this study was to investigate the respective contributions of Tl-201 and I-123-IMT single-photon emission tomography (SPET) in the non-invasive evaluation of intracerebral rumours, We analysed 65 patients with the following brain rumours: 8 non-neoplastic lesions, 4 meningiomas, 12 low-grade gliomas, 28 high-grade gliomas, 11 metastases and 2 high-grade lymphomas. Tl-201 SPET and I-123-IMT SPET were performed [start of Tl-201 SPET: 15 min p.i. (early) and 180 min p.i. (delayed); start of I-123-IMT SPET: 15 min p.i.]. The intensity of uptake was quantified as the ratio between tracer accumulation in the tumour and in the contralateral hemisphere. None of the non-neoplastic lesions or low-grade gliomas expressed mal ked Tl-201 uptake. Allmalignant tumours except one small metastasis and all meningiomas except one small, cystic and degenerated lesion showed significant Tl-201 accumulation [Tl(15')>2.0]; I-123-IMT uptake was either absent or intermediate in non-malignant lesions except in two low-grade gliomas; the highest levels were observed in high-grade gliomas followed by metastases and lymphomas (meanIMT: 2.7 vs 2.1 vs 1.8), with metastases showing a high variability in I-123-IMT uptake (range: 0.8-3.6), Using Tl-201 to distinguish non-neoplastic lesions from malignant tumours and meningiomas, 63 of 65 patients were characterised correctly. In the latter group, high-grade gliomas were correctlyidentified in 37 of 28 cases by their amino acid uptake, It is concluded that the combination of Tl-201 and I-123-IMT surpasses the accuracy of each single test in the differentiation of space-occupying lesions of the brain. Based on these preliminary results, a sequential strategy is proposed involving an initial Tl-201 SPET study and an additional I-123-IMT SPET study in the event of positive Tl-201 up take.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 12:21:49