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Titolo:
Protection against dopaminergic nigrostriatal cell death by excitatory input ablation
Autore:
Takada, M; Matsumura, M; Kojima, J; Yamaji, Y; Inase, M; Tokuno, H; Nambu, A; Imai, H;
Indirizzi:
Tokyo Metropolitan Inst Neurosci, Tokyo 1838526, Japan Tokyo Metropolitan Inst Neurosci Tokyo Japan 1838526 okyo 1838526, Japan Japan Sci & Technol, CREST, Tokyo, Japan Japan Sci & Technol Tokyo Japan apan Sci & Technol, CREST, Tokyo, Japan Gunma Univ, Sch Med, Dept Neurosurg, Maebashi, Gumma 3718513, Japan Gunma Univ Maebashi Gumma Japan 3718513 g, Maebashi, Gumma 3718513, Japan Sayama Neurol hosp, Dept Neurol, Sayama, Saitama 3501302, Japan Sayama Neurol hosp Sayama Saitama Japan 3501302 a, Saitama 3501302, Japan Juntendo Univ, Sch Med, Dept Publ Hlth, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 , Dept Publ Hlth, Tokyo 1138421, Japan Kinki Univ, Sch Med, Dept Physiol, Sayama, Osaka 5898511, Japan Kinki Univ Sayama Osaka Japan 5898511 ysiol, Sayama, Osaka 5898511, Japan Juntendo Univ, Sch Med, Dept Neurol, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 Med, Dept Neurol, Tokyo 1138421, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 12, anno: 2000,
pagine: 1771 - 1780
SICI:
0953-816X(200005)12:5<1771:PADNCD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDUNCULOPONTINE TEGMENTAL NUCLEUS; NIGRA-PARS-COMPACTA; PROGRESSIVE SUPRANUCLEAR PALSY; RAT SUBSTANTIA-NIGRA; SINGLE-UNIT-ACTIVITY; BASAL GANGLIA; PARKINSONS-DISEASE; SUBTHALAMIC NUCLEUS; SQUIRREL-MONKEY; MESOPONTINE TEGMENTUM;
Keywords:
glutamate; MPTP; Parkinson's disease; pedunculopontine tegmental nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Takada, M Tokyo Metropolitan Inst Neurosci, Tokyo 1838526, Japan Tokyo Metropolitan Inst Neurosci Tokyo Japan 1838526 26, Japan
Citazione:
M. Takada et al., "Protection against dopaminergic nigrostriatal cell death by excitatory input ablation", EUR J NEURO, 12(5), 2000, pp. 1771-1780

Abstract

The importance of enhanced glutamatergic neurotransmission in the basal ganglia and related structures has recently been highlighted in the development of Parkinson's disease. The pedunculopontine tegmental nucleus (PPN) is the major origin of excitatory, glutamatergic input to dopaminergic nigrostriatal neurons of which degeneration is well known to cause Parkinson's disease. Based on the concept that an excitatory mechanism mediated by glutamatergic neurotransmission underlies the pathogenesis of neurodegenerative disorders, we made an attempt to test the hypothesis that removal of the glutamatergic input to the nigrostriatal neurons by PPN lesions might prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey. The PPN was lesioned unilaterally with microinjection of kainic acid, and, then, MPTP was administered systemically. In these monkeys, the degree of parkinsonian motor signs was behaviourally evaluated, and the histological changes in the dopaminergic nigrostriatal system were analysed by means of tyrosine hydroxylase immunohistochemistry. The present results revealed that nigrostriatal cell loss and parkinsonian motor deficits were largely attenuated in the MPTP-treated monkey group whose PPN had been lesioned, compared with the control, MPTP-treated monkey group with the PPN intact. This clearly indicates that the onset of MPTP neurotoxicity is suppressed or delayed by experimental ablation of the glutamatergic input to the nigrostriatal neurons. Such a protective action of excitatory input ablation against nigrostriatal cell death defines evidence that nigral excitation driven by the PPN may be implicated in the pathophysiology of Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:12:26