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Titolo:
MafB is an inducer of monocytic differentiation
Autore:
Kelly, LM; Englmeier, U; Lafon, I; Sieweke, MH; Graf, T;
Indirizzi:
CNRS, INSERM, Ctr Immunol Marseille Luminy, F-13288 Marseille 09, France CNRS Marseille France 09 Marseille Luminy, F-13288 Marseille 09, France Albert Einstein Coll Med, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Coll Med, Bronx, NY 10461 USA
Titolo Testata:
EMBO JOURNAL
fascicolo: 9, volume: 19, anno: 2000,
pagine: 1987 - 1997
SICI:
0261-4189(20000502)19:9<1987:MIAIOM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
E26 LEUKEMIA-VIRUS; TRANSCRIPTION FACTOR NF-E2; COLONY-STIMULATING FACTOR; BINDING PROTEIN-ALPHA; HEMATOPOIETIC PROGENITORS; MONOCLONAL-ANTIBODIES; LINEAGE COMMITMENT; MYELOID CELLS; MACROPHAGE DIFFERENTIATION; ERYTHROID-DIFFERENTIATION;
Keywords:
hematopoiesis; kreisler; MafB; Maf proteins; macrophages; myeloid differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Sieweke, MH CNRS, INSERM, Ctr Immunol Marseille Luminy, Parc Sci & TechnolLuminy,Case906, F-13288 Marseille 09, France CNRS Parc Sci & Technol Luminy,Case 906 Marseille France 09 e
Citazione:
L.M. Kelly et al., "MafB is an inducer of monocytic differentiation", EMBO J, 19(9), 2000, pp. 1987-1997

Abstract

The bZip transcription factor MafB is expressed specifically in the myeloid lineage of the hematopoietic system and is up-regulated successively during myeloid differentiation from multipotent progenitors to macrophages. Here we report that this induction reflects an essential role of MafB in earlymyeloid and monocytic differentiation. We observed that the expression of MafB in transformed chicken hematopoietic precursors dramatically increasesthe proportion of myeloid colony formation at the expense of multipotent progenitor-type colonies. In addition, the overexpression of MafB in transformed myeloblasts stimulates the rapid formation of macrophages, as judged by morphology, surface marker expression and functional criteria. MafB-induced macrophages exhibit typical levels of phagocytic activity and nitric oxide release after activation by lipopolysaccharide, By contrast? overexpression of the myeloid transcription factor PU.1 in these cells does not inducemacrophage differentiation. Furthermore, a dominant-negative allele of MafB inhibits both myeloid colony formation and the differentiation of myeloblasts into macrophages. Taken together, our results indicate that MafB induction is a specific and essential determinant of the monocytic program in hematopoietic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:14:24