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Titolo:
Determination of clozapine by capillary zone electrophoresis following end-column amperometric detection with simplified capillary/electrode alignment
Autore:
Jin, WR; Xu, Q; Li, W;
Indirizzi:
Shandong Univ, Sch Chem, Analyt Sci Lab, Jinan 250100, Peoples R China Shandong Univ Jinan Peoples R China 250100 Jinan 250100, Peoples R China Anim Husb Bur Shandong Prov, Jinan, Peoples R China Anim Husb Bur ShandongProv Jinan Peoples R China inan, Peoples R China Hlth & Dis Prevent Ctr Shandong Prov, Jinan, Peoples R China Hlth & Dis Prevent Ctr Shandong Prov Jinan Peoples R China ples R China
Titolo Testata:
ELECTROPHORESIS
fascicolo: 7, volume: 21, anno: 2000,
pagine: 1415 - 1420
SICI:
0173-0835(200004)21:7<1415:DOCBCZ>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; MICRODISK ARRAY ELECTRODE; SOLID-PHASE EXTRACTION; GOLD/MERCURY AMALGAM MICROELECTRODE; ULTRAVIOLET DETECTION; HUMAN SERUM; HUMAN-PLASMA; DESMETHYLCLOZAPINE; ADSORPTION; ADENINE;
Keywords:
capillary electrophoresis; electrochemical detection; clozapine; drug; blood;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, WR Shandong Univ, Sch Chem, Analyt Sci Lab, Jinan 250100, Peoples R China Shandong Univ Jinan Peoples R China 250100 0100, Peoples R China
Citazione:
W.R. Jin et al., "Determination of clozapine by capillary zone electrophoresis following end-column amperometric detection with simplified capillary/electrode alignment", ELECTROPHOR, 21(7), 2000, pp. 1415-1420

Abstract

Capillary zone electrophoresis was employed for the determination of clozapine using an end-column amperometric detection at a carbon fiber array microdisk electrode with simplified capillary/electrode alignment. The optimumconditions of separation and detection are: Britton-Robinson butter, pH 2.0 (1.3 x 10(-2) mol/L total concentration of acids, 3.2 x 10(-3) mol/L NaOH), 15 kV for separation voltage, 5 kV and 10 s for injection voltage and injection time, respectively. The limit of detection is 4.2 x 10(-7) mol/L or1.2 fmole (signal to noise, S/N = 2). The relative standard deviation is 1.4% for the migration time and 2.5% for the electrophoretic peak current. The method was applied to the determination of clozapine in human blood. Therecovery of the method is between 94-104%.

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Documento generato il 24/01/20 alle ore 15:51:43