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Titolo:
Quantitative assay of metronidazole by capillary zone electrophoresis withamperometric detection at a gold microelectrode
Autore:
Jin, WR; Li, W; Xu, Q; Dong, Q;
Indirizzi:
Shandong Univ, Sch Chem, Analyt Sci Lab, Jinan 250100, Peoples R China Shandong Univ Jinan Peoples R China 250100 Jinan 250100, Peoples R China Hlth & Dis Prevent Ctr Shandong Prov, Jinan, Peoples R China Hlth & Dis Prevent Ctr Shandong Prov Jinan Peoples R China ples R China Anim Husb Bur Shandong Prov, Jinan, Peoples R China Anim Husb Bur ShandongProv Jinan Peoples R China inan, Peoples R China
Titolo Testata:
ELECTROPHORESIS
fascicolo: 7, volume: 21, anno: 2000,
pagine: 1409 - 1414
SICI:
0173-0835(200004)21:7<1409:QAOMBC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICRODISK ARRAY ELECTRODE; GOLD/MERCURY AMALGAM MICROELECTRODE; PERFORMANCE LIQUID-CHROMATOGRAPHY; ADENINE; SERUM; DEOXYGENATION; ADSORPTION; EFFICIENCY; ORNIDAZOLE; ADENOSINE;
Keywords:
capillary electrophoresis; electrochemical detection; metronidazole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, WR Shandong Univ, Sch Chem, Analyt Sci Lab, Jinan 250100, Peoples R China Shandong Univ Jinan Peoples R China 250100 0100, Peoples R China
Citazione:
W.R. Jin et al., "Quantitative assay of metronidazole by capillary zone electrophoresis withamperometric detection at a gold microelectrode", ELECTROPHOR, 21(7), 2000, pp. 1409-1414

Abstract

Capillary zone electrophoresis was employed for the determination of metronidazole using end-column amperometric detection with a gold microelectrodeat a constant potential of -0.52V vs, saturated calomel electrode. To overcome interference of oxygen in the solution, a deaeration injector and a deaeration protector at the detection cell were used. The optimum conditions of separation and detection are 1.0 x 10(-3) mol/L potassium dihydrogen citrate (KH2C6H5O7) for the buffer solution, 20 kV for the separation voltage,and 5 kV and 10 S for injection voltage and injection time, respectively. The limit of detection is 6.0 x 10(7) mol/L or 0.78 fmole (S/N = 3). The relative standard deviation is 3.9% for the electrophoretic peak current. Themethod was applied to the determination of metronidazole in human urine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:06:21