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Titolo:
Regulators of vascular permeability: potential sites for intervention in the treatment of macular edema
Autore:
Gillies, MC;
Indirizzi:
Univ Sydney, Save Sight Inst, Sydney, NSW 2001, Australia Univ Sydney Sydney NSW Australia 2001 t Inst, Sydney, NSW 2001, Australia
Titolo Testata:
DOCUMENTA OPHTHALMOLOGICA
fascicolo: 3-4, volume: 97, anno: 1999,
pagine: 251 - 260
SICI:
0012-4486(1999)97:3-4<251:ROVPPS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; ENDOTHELIAL ALBUMIN PERMEABILITY; ADHESION MOLECULE UVOMORULIN; THROMBIN-INDUCED INCREASE; ADHERENS-TYPE JUNCTIONS; BLOOD-BRAIN-BARRIER; TYROSINE PHOSPHORYLATION; CELL-ADHESION; IN-VITRO; EPITHELIAL-CELLS;
Keywords:
blood-retinal barrier; drug therapy; endothelium; vascular; permeability; protein kinase C; tyrosine phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Gillies, MC Univ Sydney, Save Sight Inst, Box 4337, Sydney, NSW 2001, Australia Univ Sydney Box 4337 Sydney NSW Australia 2001 2001, Australia
Citazione:
M.C. Gillies, "Regulators of vascular permeability: potential sites for intervention in the treatment of macular edema", DOC OPHTHAL, 97(3-4), 1999, pp. 251-260

Abstract

Rather than being a non-specific reaction to a noxious stimulus, breakdownof the capillary blood-retinal barrier causing macular edema appears to bedependent on a number of active processes which may be open to pharmacological manipulation. Extracellular influences which may affect barrier function include serum and neighboring cell types, which act though cytokines, such as vascular endothelial growth factor and transforming growth factor-ss,and other factors. A number of intracellular pathways acting on the cytoskeleton and components of the intercellular junctional complexes have been identified which mediate agonist-induced leak of the vascular endothelium. The further elucidation of these processes may be useful in the development of better treatments for breakdown of the inner blood-retinal barrier.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:17:58