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Titolo:
Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose - A direct metformin effect on pancreatic beta-cells
Autore:
Patane, G; Piro, S; Rabuazzo, AM; Anello, M; Vigneri, R; Purrello, F;
Indirizzi:
Univ Catania, Osped Garibaldi, Ctr Diabetol S Signorelli, Dept Internal Med, I-95123 Catania, Italy Univ Catania Catania Italy I-95123 Internal Med, I-95123 Catania, Italy Univ Catania, Osped Garibaldi, Ctr Diabetol S Signorelli, Dept Endocrinol,I-95123 Catania, Italy Univ Catania Catania Italy I-95123 ept Endocrinol,I-95123 Catania, Italy Univ Catania, Osped Garibaldi, Ctr Diabetol S Signorelli, Dept Metab, I-95123 Catania, Italy Univ Catania Catania Italy I-95123 i, Dept Metab, I-95123 Catania, Italy
Titolo Testata:
DIABETES
fascicolo: 5, volume: 49, anno: 2000,
pagine: 735 - 740
SICI:
0012-1797(200005)49:5<735:MRISAB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRUVATE-DEHYDROGENASE ACTIVITY; DEPENDENT DIABETES-MELLITUS; RAT ISLETS; MALONYL-COA; LIPOTOXICITY; OXIDATION; THERAPY; LEPTIN; OBESE; NIDDM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Purrello, F Univ Catania, Osped Garibaldi, Ctr Diabetol S Signorelli, DeptInternal Med, Piazza S Maria di Gesu, I-95123 Catania, Italy Univ Catania Piazza S Maria di Gesu Catania Italy I-95123 aly
Citazione:
G. Patane et al., "Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose - A direct metformin effect on pancreatic beta-cells", DIABETES, 49(5), 2000, pp. 735-740

Abstract

Because metformin affects glucose and free fatty acid (FFA) metabolism in peripheral insulin target tissues, we investigated the effect of this drug in restoring a normal secretory pattern in rat pancreatic islets whose function has been impaired by chronic exposure to elevated FFA or glucose concentrations. We cultured rat pancreatic islets with or without FFA (2 mmol/l oleate/ palmitate 2:1) or high glucose (16.7 mmol/l) concentrations in the presence or absence of metformin (0.25-12.5 mu g/ml) and then measured insulin release, glucose utilization, glucose, and FFA oxidation. When comparedwith control islets, islets exposed to high FFA or glucose concentrations showed an increased basal and a decreased glucose-induced insulin release. In islets cultured for an additional 24 h with FFA or glucose in the presence of metformin (2.5 mu g/ml), both basal and glucose-induced insulin secretions were restored. Both glucose utilization and glucose oxidation were altered in islets pre-exposed to high FFA or glucose concentrations. In particular, regarding control islets, glucose utilization was increased at 2.8 mmol/l glucose and decreased at 16.7 mmol/l glucose; glucose oxidation was similar to control islets at 2.8 mmol/l glucose but decreased at 16.7 mmol/lglucose. In contrast, oleate oxidation was increased in islets pre-exposedto FFA. AU of these abnormalities were reversed in islets cultured for an additional 24 h with high FFA or glucose concentrations in the presence of metformin (2.5 mu g/ml). In conclusion, our data show that metformin is able to restore the intracellular abnormalities of glucose and FFA metabolism and to restore a normal secretory pattern in rat pancreatic islets whose secretors function has been impaired by chronic exposure to elevated FFA or glucose levels. These data raise the possibility that, in diabetic patients,metformin tin addition to its peripheral effects) may have a direct beneficial effect on the beta-cell secretory function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:22:14