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Titolo:
Effect of dobutamine on myocardial blood flow in patients with coronary artery disease - a quantitative analysis using O-15 H2O positron emission tomography
Autore:
Schneider, CA; Voth, E; Moka, D; Wagner, R; Schicha, H; Erdmann, E; Baer, FM;
Indirizzi:
Univ Cologne, Innere Med Klin 3, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 ed Klin 3, D-50924 Cologne, Germany Univ Cologne, Klin & Poliklin Nukl Med, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 Nukl Med, D-50924 Cologne, Germany Univ Cologne, Max Planck Inst Neurol Forsch, D-50924 Cologne, Germany UnivCologne Cologne Germany D-50924 ol Forsch, D-50924 Cologne, Germany
Titolo Testata:
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
fascicolo: 17, volume: 125, anno: 2000,
pagine: 512 - 516
Fonte:
ISI
Lingua:
GER
Soggetto:
STRESS ECHOCARDIOGRAPHY; N-13 AMMONIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Schneider, CA Univ Cologne, Innere Med Klin 3, Joseph Stelzmann Str 9, D-50924 Cologne, Germany Univ Cologne Joseph Stelzmann Str 9 Cologne Germany D-50924
Citazione:
C.A. Schneider et al., "Effect of dobutamine on myocardial blood flow in patients with coronary artery disease - a quantitative analysis using O-15 H2O positron emission tomography", DEUT MED WO, 125(17), 2000, pp. 512-516

Abstract

Background and objective: Although dobutamine is currently widely used forstress testing, only little is known about the effects of dobutamine on myocardial blood flow. The purpose of the present study was therefore to analyze quantitatively the regional changes in myocardial blood flow during rest and stress. Patients and methods: In order to assess these effects 17 patients (12 men, five women, mean age 57 +/- 8 years) with symptomatic single vessel coronary artery disease (>70% stenosis) scheduled for coronary angioplasty underwent dobutamine stress testing with a maximum dose of 40 mu g/kg/min. Myocardial blood flow was measured using O-15 H2O positron emission tomography at rest and during maximum stress in ischemic and non-ischemic myocardial regions. Results: Dobutamine stress (median dose 30 mu g/kg/min) increased the Fatepressure product significantly (from rest 8697 [95% confidence interval 7959-9435] to stress 16 512 [15 208-17 815] mmHg/min (p < 0.007). Myocardial blood flow during rest was similar in non-ischaemic and ischaemic regions (0,91 [0.93; 0.83-1.28] vs. 1.10 [1.23; 0.91-1.28] ml/min/g, n.s.). During dobutamine stress myocardial blood flow increased in non-ischaemic regions to 2.17 (2.15; 1.77-2.57) ml/min/g, while myocardial blood flow did not increase in ischaemic regions (1.06 [0.97; 0.83-1.28], p < 0.001). Accordingly,dobutamine coronary reserve was 2.42 (2,55; 2,10-2,74) for non-ischaemic regions and 0.98 (1.05; 0.84-1.13) for ischemic regions (p < 0.001). Rate pressure product and myocardial blood flow were significantly correlated(r = 0.79, p < 0.001). Conclusion:A dobutamine-induced increase in rate pressure product was proportional to an increase in myocardial blood flow in non-ischaemic regions. In contrast, myocardial blood flow did not increase in myocardial regions supplied by a severely stenosed coronary artery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 08:10:34