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Titolo:
Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines
Autore:
Holm, T; Aukrust, P; Andreassen, AK; Ueland, T; Brosstad, F; Froland, SS; Simonsen, S; Gullestad, L;
Indirizzi:
Univ Oslo, Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Rikshosp, Dept Cardiol, N-0027 Oslo, Norway
Titolo Testata:
CLINICAL TRANSPLANTATION
fascicolo: 3, volume: 14, anno: 2000,
pagine: 218 - 225
SICI:
0902-0063(200006)14:3<218:PEDIHT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOTOPIC CARDIAC TRANSPLANTATION; CORONARY-ARTERY DISEASE; TUMOR-NECROSIS-FACTOR; DEPENDENT VASODILATION; SKIN MICROCIRCULATION; FOREARM CIRCULATION; CYCLOSPORINE-A; NITRIC-OXIDE; TNF-ALPHA; FAILURE;
Keywords:
peripheral endothelial dysfunction; proinflammatory cytokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Holm, T Univ Oslo, Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 , Dept Cardiol, N-0027 Oslo, Norway
Citazione:
T. Holm et al., "Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines", CLIN TRANSP, 14(3), 2000, pp. 218-225

Abstract

Endothelium-dependent vasodilation in the peripheral circulation may be impaired in heart transplant recipients (HTx rec). Conflicting results have been obtained and the mechanisms involved have not been examined. In the present study, we examined whether long-time survivors of heart transplantation (Tx) show signs of endothelial dysfunction in the peripheral microcirculation, and further investigated the possible role of endothelium-related markers and proinflammatory cytokines in this process. The vasodilatory responses to acetylcholine (Ach) (endothelium-dependent) and sodium nitroprusside(SNP) (endothelium-independent) were evaluated by skin laser-Doppler perfusion measurements in 63 clinically stable HTx rec 6 yr (range 1-13 yr) after Tx, and compared with 20 healthy controls. Ten HTx rec were also followedprospectively with three repeated measurements during the first year afterTx. Plasma von Willebrand factor, big-endothelin (b-ET), and proinflammatory cytokines were measured by enzyme immunoassays. Vascular responses to both Ach and SNP were significantly attenuated in the HTx rec compared with controls. In longitudinal testing, there was a significant reduction in endothelium-dependent vasodilation, but not independent vasodilation from 1 to 12 months after Tx. Plasma levels of VWF and b-ET, as well as levels of proinflammatory cytokines, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1 beta, were all markedly increased in HTx rec. HTx rec responsesto Ach were negatively correlated to TNF-alpha levels in plasma (r = - 0.39, P < 0.01). Moreover, there was also a significant positive correlation between plasma b-ET and TNF-alpha (r = 0.3-1, p < 0.01). In the long-term follow-up of HTx rec, endothelial dysfunction is demonstrated by both regulation of blood flow in the skin microcirculation and by raised markers of endothelial activation in plasma. This endothelial dysfunction may be related to enhanced levels of proinflammatory cytokines in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:57:14