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Titolo:
mei-41 is required for precocious anaphase in Drosophila females
Autore:
McKim, KS; Jang, JK; Sekelsky, JJ; Laurencon, A; Hawley, RS;
Indirizzi:
Univ Calif Davis, Sect Mol & Cellular Biol, Davis, CA 95616 USA Univ CalifDavis Davis CA USA 95616 & Cellular Biol, Davis, CA 95616 USA Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Inst, Piscataway, NJ 08854 USA Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 enet, Piscataway, NJ 08854 USA
Titolo Testata:
CHROMOSOMA
fascicolo: 1-2, volume: 109, anno: 2000,
pagine: 44 - 49
SICI:
0009-5915(200004)109:1-2<44:MIRFPA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEIOTIC RECOMBINATION; METAPHASE ARREST; MELANOGASTER; HOMOLOG; MECHANISM; OOGENESIS; SYNAPSIS; MUTANTS; MEIOSIS; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Hawley, RS Univ Calif Davis, Sect Mol & Cellular Biol, Davis, CA 95616 USAUniv Calif Davis Davis CA USA 95616 Biol, Davis, CA 95616 USA
Citazione:
K.S. McKim et al., "mei-41 is required for precocious anaphase in Drosophila females", CHROMOSOMA, 109(1-2), 2000, pp. 44-49

Abstract

This paper reports on a new role for mei-41 in cell cycle control during meiosis. This function is revealed by the requirement of mei-41 for the precocious anaphase observed in crossover-defective mutants. Normally in Drosophila oocytes, tension on the meiotic spindle causes a metaphase I arrest. This tension results because crossovers, and the resulting chiasmata, hold homologs together that are being pulled by kinetochore microtobules toward opposite spindle poles. In the absence of tension, such as in a recombination-defective mutant, metaphase arrest is not observed and meiosis proceeds through the two divisions. Here we show that in some recombination-defectivemutants, the precocious anaphase requires the mei-41 gene product, For example, metaphase arrest is not observed in mei-218 mutants because of the severe reduction in crossing over. In mei-41 mei-218 double mutants, however,metaphase arrest was restored. The effect of mei-41 is dependent on double-strand break formation. Thus, in mutants that fail to initiate meiotic recombination the absence of mei-41 has no effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:20:13