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Titolo:
Target-cell-induced anergy in natural killer cells: suppression of cytotoxic function
Autore:
Das, S; Varalakshmi, C; Khar, A;
Indirizzi:
Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Hyderabad Andhra Pradesh India 500007 desh, India
Titolo Testata:
CANCER IMMUNOLOGY IMMUNOTHERAPY
fascicolo: 2, volume: 49, anno: 2000,
pagine: 109 - 115
SICI:
0340-7004(200005)49:2<109:TAINKC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS TNF-ALPHA; NK CELLS; PIVOTAL ROLE; INACTIVATION; HISTIOCYTOMA; APOPTOSIS; ANTIBODY; REGRESSION; ACTIVATION; THYMOCYTES;
Keywords:
NK cell anergy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Khar, A Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Uppal Rd Hyderabad Andhra Pradesh India 500007
Citazione:
S. Das et al., "Target-cell-induced anergy in natural killer cells: suppression of cytotoxic function", CANCER IMMU, 49(2), 2000, pp. 109-115

Abstract

Our earlier studies have demonstrated that natural killer (NK) cells are the effecters that participate during the spontaneous regression of AK-5 tumour in syngeneic hosts. We have shown that the tumour cells are killed by necrosis and apoptosis. In this study, we have examined the induction of functional anergy in NK cells following coculture with fixed AK-5 tumour cellsat high ratio. NK cells, upon coculture with fixed AK-5 cells (1:1 ratio),showed loss of cytotoxic function against both AK-5 (antibody-dependent cell cytotoxicity) as well as YAC-1 targets. The response of these cells to the activation by recombinant interleukin-2 and recombinant interferon gammawas poor. Induction of tumour necrosis factor alpha (TNF alpha) secretion was observed after coculture of NK cells with fixed AK-5 cells. The cocultured cell supernatant inhibited the cytotoxic activity of NK cells, which was partially restored with anti-TNF alpha antibody. In addition, NK cells, after treatment with fixed tumour cells showed overexpression of the Fas receptor. We have also observed induction of apoptosis in cocultured NK cells. These studies suggest that the fixed tumour cells (antigen) at high ratio are able to suppress NK cell function as well as induce death in NK cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:18:22