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Titolo:
Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-transretinoic acid
Autore:
Kitamura, K; Hoshi, S; Koike, M; Kiyoi, H; Saito, H; Naoe, T;
Indirizzi:
Nagoya Univ, Sch Med, Dept Infect Dis, Nagoya, Aichi 4668560, Japan NagoyaUniv Nagoya Aichi Japan 4668560 Dis, Nagoya, Aichi 4668560, Japan Kamaishi Municipal Hosp, Dept Internal Med, Kamaishi, Japan Kamaishi Municipal Hosp Kamaishi Japan pt Internal Med, Kamaishi, Japan St Marianna Med Sch, Dept Haematol & Oncol, Kawasaki, Kanagawa, Japan St Marianna Med Sch Kawasaki Kanagawa Japan l, Kawasaki, Kanagawa, Japan Nagoya Univ, Sch Med, Dept Internal Med 1, Nagoya, Aichi 466, Japan NagoyaUniv Nagoya Aichi Japan 466 ternal Med 1, Nagoya, Aichi 466, Japan
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 4, volume: 108, anno: 2000,
pagine: 696 - 702
SICI:
0007-1048(200003)108:4<696:HDIBNA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PML-RAR-ALPHA; RESISTANT NB4 CELLS; RECEPTOR-ALPHA; COMPLETE REMISSION; DOWN-REGULATION; LEUKEMIA-CELLS; TRICHOSTATIN-A; FUSION; TRANSLOCATION; APOPTOSIS;
Keywords:
acute promyelocytic leukaemia; differentiation; all-trans retinoic acid; histone deacetylase inhibitor; arsenic trioxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Naoe, T Nagoya Univ, Sch Med, Dept Infect Dis, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 goya, Aichi 4668560, Japan
Citazione:
K. Kitamura et al., "Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-transretinoic acid", BR J HAEM, 108(4), 2000, pp. 696-702

Abstract

Acute promyelocytic leukaemia (APL) with t(11;17)/PLZF-RAR alpha responds poorly to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3), in contrast to APL with t(15;17)/PML-RAR alpha. Molecular studies have shown that histone deacetylase (HDAC) recruited by PLZF-RAR alpha is associated with the ATRA resistance. Here, we analysed in vitro the differentiation of APL cells with t(11;17) using ATRA, As2O3, granulocyte colony-stimulating factor (G-CSF), HDAC inhibitor trichostatin A (TSA), or combinations of these. Although 1 mu M ATRA, which stimulated the differentiation of APL cells with t(15;17), was insufficient to induce differentiation, 3 mu M ATRA induced terminal differentiation into granulocytes. As2O3 alone or in combinationwith ATRA induced neither differentiation nor apoptosis. However, the combination of TSA and 1 mu M ATRA had a potent differentiating effect, although TSA alone had little effect. The combination of 1 mu M ATRA and G-CSF didnot induce differentiation. These results indicate that APL cells with t(11;17) need a higher concentration of ATRA than those with t(15;17) to differentiate and suggest that HDAC inhibitor is a promising differentiation enhancer in APL with t(11;17).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:06:11