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Titolo:
Encouraging results in the treatment of haemorrhagic cystitis with estrogen - report of 10 cases and review of the literature
Autore:
Ordemann, R; Naumann, R; Geissler, G; Bornhauser, M; Schuler, U; Ehninger, G;
Indirizzi:
Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Med 1, D-01307 Dresden, Germany Tech Univ Dresden Dresden Germany D-01307 ed 1, D-01307 Dresden, Germany
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 9, volume: 25, anno: 2000,
pagine: 981 - 985
SICI:
0268-3369(200005)25:9<981:ERITTO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEMORRHAGIC CYSTITIS; BONE-MARROW TRANSPLANTATION; CONJUGATED ESTROGEN; THERAPY; RISK; RADIATION; MESNA; CELLS;
Keywords:
haemorrhagic cystitis; haematopoietic stem cell transplantation; cyclophosphamide; estrogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ehninger, G Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Med 1, Festscherstr 74, D-01307 Dresden, Germany Tech Univ Dresden Festscherstr 74 Dresden Germany D-01307 any
Citazione:
R. Ordemann et al., "Encouraging results in the treatment of haemorrhagic cystitis with estrogen - report of 10 cases and review of the literature", BONE MAR TR, 25(9), 2000, pp. 981-985

Abstract

Haemorrhagic cystitis (HC) after allogeneic haematopoietic stem cell transplantation (HSCT) or high-dose cyclophosphamide (CP) chemotherapy is a severe side-effect and can cause significant morbidity and mortality. In this report, we describe the clinical courses of 10 patients with HC and review the literature. The patients were treated with oral conjugated estrogen in an attempt to improve severe haemorrhagic cystitis. In seven patients positive effects were seen, haematuria resolved in all, but residual symptoms of dysuria remained for longer periods. In one patient application of estrogenwas interrupted because of hepatotoxicity. Two patients failed all treatment modalities including oral estrogen because of terminal illness. We conclude that in the management of HC the administration of oral conjugated estrogen should be considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:29:33