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Titolo:
Osmomechanical regulation of membrane trafficking in polarized cells
Autore:
Reid, JM; ONeil, RG;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 t Biol & Pharmacol, Houston, TX 77030 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 271, anno: 2000,
pagine: 429 - 434
SICI:
0006-291X(20000510)271:2<429:OROMTI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL TUBULE CELLS; INTRACELLULAR CALCIUM; VOLUME REGULATION; PLASMA-MEMBRANE; EXOCYTOSIS; ENDOCYTOSIS; FLUORESCENCE; MECHANISMS; SECRETION; CAPACITANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: O'Neil, RG Univ Texas, Hlth Sci Ctr, Dept Integrat Biol & Pharmacol, 6431 Fannin, Houston, TX 77030 USA Univ Texas 6431 Fannin Houston TX USA 77030 uston, TX 77030 USA
Citazione:
J.M. Reid e R.G. O'Neil, "Osmomechanical regulation of membrane trafficking in polarized cells", BIOC BIOP R, 271(2), 2000, pp. 429-434

Abstract

The regulation of membrane trafficking is thought to be predominantly under the control of agonist-receptor transduction pathways. In the present study, osmomechanical stress due to swelling, a condition often accompanying cell activation, was shown to induce multiple membrane trafficking pathways in polarized absorptive epithelial cells in the absence of agonists. Osmomechanical stress activated rapidly (seconds) pathways of calcium-dependent membrane insertion into the basolateral domain, pathways of calcium-independent membrane retrieval from the basolateral domain, and a novel pathway of transcytosis (transcellular) between basolateral and apical cell domains. These pathways appear to underlie the transfer and regulation of transport proteins amongst cell compartments. This broad affect of osmomechanical stress on trafficking pathways may reflect a global mechanism for redistribution of transport proteins and other membrane components amongst cell compartments during states of mechanical stress. (C) 2000 Academic Press.

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Documento generato il 04/07/20 alle ore 19:36:00