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Titolo:
Enhanced macrophage uptake of elastase-modified high-density lipoproteins
Autore:
Pirillo, A; Ghiselli, G;
Indirizzi:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Ist Sci Farmacol, Dept Pharmacol, Milan, Italy Ist Sci Farmacol Milan Italy Sci Farmacol, Dept Pharmacol, Milan, Italy
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 271, anno: 2000,
pagine: 386 - 391
SICI:
0006-291X(20000510)271:2<386:EMUOEH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-I; BLOOD POLYMORPHONUCLEAR CELLS; SCAVENGER RECEPTOR; CHOLESTEROL; EXPRESSION; FIBROBLASTS; INCUBATION; INVITRO; PLASMA; CD36;
Keywords:
high-density lipoproteins; macrophages; atherosclerosis; lipoprotein scavenger receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ghiselli, G Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, 260 S 11th St, Philadelphia, PA 19107 USA Thomas Jefferson Univ 260 S 11th St Philadelphia PA USA 19107
Citazione:
A. Pirillo e G. Ghiselli, "Enhanced macrophage uptake of elastase-modified high-density lipoproteins", BIOC BIOP R, 271(2), 2000, pp. 386-391

Abstract

Incubation of human HDL (d = 1.063-1.21 g/ml) with monocyte-derived elastase causes selective proteolysis of apoA-II and apoA-I apolipoproteins. me have found that elastase-digested HDL (ED-HDL) bind to J774-Al murine macrophages with enhanced affinity and are internalized and degraded at a rate threefold higher than that of native HDL. Unlike oxidized LDL and HDL and proteolytically modified LDL, the uptake of ED-HDL lipoproteins does not affect the cellular Lipid biosynthesis nor modify the cell lipid content. The cell surface binding of I-125-ED-HDL can be competed by native HDL but not byacetylated LDL, consistent with the idea that ED-HDL are recognized by theclass B type I scavenger receptor. The liberation of elastase by lipid-engorging macrophages is regarded as an important event during atherogenesis. By enhancing the cellular uptake of HDL this process can lead to a local decrease of antiatherogenic HDL particles. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 17:07:58