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Titolo:
Contextual fear, gestalt memories, and the hippocampus
Autore:
Fanselow, MS;
Indirizzi:
Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA Univ CalifLos Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Inst Brain Res, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 110, anno: 2000,
pagine: 73 - 81
SICI:
0166-4328(20000601)110:1-2<73:CFGMAT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; DEFENSIVE REACTIONS; DORSAL HIPPOCAMPUS; RETROGRADE-AMNESIA; NUCLEUS-ACCUMBENS; RATS; LESIONS; AMYGDALA; STARTLE; CUES;
Keywords:
hippocampus; fear; context conditioning; freezing; nucleus accumbens; subiculum; exploration; hyperactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Fanselow, MS Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 CA 90095 USA
Citazione:
M.S. Fanselow, "Contextual fear, gestalt memories, and the hippocampus", BEH BRA RES, 110(1-2), 2000, pp. 73-81

Abstract

This review examines the relationship between exploration and contextual fear conditioning. The fear acquired to places or contexts associated with aversive events is a form of Pavlovian conditioning. However, an initial period of exploration is necessary to allow the animal to form an integrated memory of the features of the context before conditioning can take place. The hippocampal formation plays a critical role in this process. Cells withinthe dorsal hippocampus are involved in the formation, storage and consolidation of this integrated representation of context. Projections from the subiculum to the nucleus accumbens regulate the exploration necessary for theacquisition of information about the features of the context. This model explains why electrolytic but not excitotoxic lesions of the dorsal hippocampus cause enhanced exploratory activity but both cause deficits in contextual fear. It also explains why retrograde amnesia of contextual fear is greater than anterograde amnesia. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:28:34