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Titolo:
Oral, but not transdermal, administration of estrogens lowers tissue-type plasminogen activator levels in humans without affecting endothelial synthesis
Autore:
Giltay, EJ; Gooren, LJG; Emeis, JJ; Kooistra, T; Stehouwer, CDA;
Indirizzi:
Free Univ Amsterdam Hosp, Dept Internal Med, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Free Univ Amsterdam Hosp, Inst Endocrinol Reprod & Metab, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Free Univ Amsterdam Hosp, Cardiovasc Res Inst, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB m, Netherlands Netherlands Orgn Appl Res, Gaubius Lab, Leiden, Netherlands Netherlands Orgn Appl Res Leiden Netherlands s Lab, Leiden, Netherlands
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 5, volume: 20, anno: 2000,
pagine: 1396 - 1403
SICI:
1079-5642(200005)20:5<1396:OBNTAO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-REPLACEMENT THERAPY; VISCERAL FAT ACCUMULATION; CORONARY HEART-DISEASE; VON-WILLEBRAND-FACTOR; GROWTH FACTOR-I; POSTMENOPAUSAL WOMEN; VENOUS OCCLUSION; COAGULATION-FACTORS; BLOOD-COAGULATION; VASCULAR-DISEASE;
Keywords:
tissue-type plasminogen activator; sex hormones; venous occlusion; endothelium; estrogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Stehouwer, CDA Free Univ Amsterdam Hosp, Dept Internal Med, POB 7057, NL-1007 MB Amsterdam, Netherlands Free Univ Amsterdam Hosp POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
E.J. Giltay et al., "Oral, but not transdermal, administration of estrogens lowers tissue-type plasminogen activator levels in humans without affecting endothelial synthesis", ART THROM V, 20(5), 2000, pp. 1396-1403

Abstract

Oral estrogen administration decreases plasma levels of tissue-type plasminogen activator (tPA), which may be explained by a decrease in endothelial tPA synthesis, an increase in its hepatic clearance, or both. In the present study, we determined (1) differences between oral (ie, via the liver) ethinyl estradiol and transdermal (ie, systemic) 17 beta-estradiol administration on plasma antigen levels of tPA and plasminogen activator inhibitor type-1 before and after 4 months of hormone administration and (2) effects on endothelial tPA synthesis, by measuring the local increase in plasma tPA during venous occlusion of the upper extremity. Thirty transsexual males (median age 32 years, range 20 to 44 years) were randomly assigned to either oral ethinyl estradiol (n=15) or transdermal 17 beta-estradiol (n=15); both treatments included the antiandrogen cyproterone acetate (CA). Ten males were treated with CA alone. Seventeen transsexual females (median age 27 years, range 18 to 37 years) were treated with intramuscular testosterone esters. Only oral ethinyl estradiol plus CA but neither transdermal 17 beta-estradiol plus CA, nor oral CA, nor parenteral testosterone lowered plasma tPA and plasminogen activator inhibitor-1 (P<0.001 for both). tPA release duringvenous occlusion was not affected by oral ethinyl estradiol plus CA in males (P=0.52) or by parenteral testosterone in females (P=0.89). These data are consistent with a previous observation, in rodents, that the decrease intPA after oral estrogen administration can be explained by an increase in hepatic tPA clearance, leaving endothelial tPA synthesis unchanged, and suggest that these mechanisms also explain the decrease in tPA in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:50:00