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Titolo:
SKELETAL-MUSCLE ABNORMALITIES IN HYPOXEMI C COPD PATIENTS
Autore:
LEVY P; WUYAM B; PEPIN JL; REUTENAUER H; PAYEN JF;
Indirizzi:
UJF,PHYSIOL LAB,PRETA GRENOBLE FRANCE
Titolo Testata:
Revue des maladies respiratoires
fascicolo: 3, volume: 14, anno: 1997,
pagine: 183 - 191
SICI:
0761-8425(1997)14:3<183:SAIHCC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
FRE
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; OBSTRUCTIVE PULMONARY-DISEASE; CONGESTIVE-HEART-FAILURE; LUNG-DISEASE; METABOLISM; EXERCISE; P-31-MRS; INVIVO; OXYGEN; SIZE;
Keywords:
HYPOXEMIA; COPD; SKELETAL MUSCLES; AEROBIC; CAPACITY; P-31 NMR SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
P. Levy et al., "SKELETAL-MUSCLE ABNORMALITIES IN HYPOXEMI C COPD PATIENTS", Revue des maladies respiratoires, 14(3), 1997, pp. 183-191

Abstract

P-31 magnetic resonance spectroscopy P-31 MRS) is a non-invasive method to evaluate high energy compounds [adenosine triphosphate (ATP), phosphorcreatin (PCr), inorganic phosphates (Pi)] and intracellular pH (pH(i)) of skeletal muscle during exercise and recovery. It is a clinically applicable method of investigation for severe COPD patients with respiratory failure since exercise is limited to a single group of muscle (calf). Pronounced alterations of muscular metabolism have been shown in these patients: (1) reduced aerobic capacity (as reflected by the ratio of Pi/PCr as a function of power and changes in recovery kinetics of PCr after exercise and (2) increased anaerobic metabolism (reflected by a decrease in intracellular pH). Four different studies reveal similar abnormalities. Acute oxygen administration partially improves these parameters, suggesting that other factors in addition to hypoxaemia may contribute to the metabolic impairment. The effects of increased physical activity on these abnormalities deserve further investigations.

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Documento generato il 02/12/20 alle ore 17:28:27