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Titolo:
Combined chemoimmunotherapy in metastatic melanoma - is there a need for the double?
Autore:
Schrader, AJ;
Indirizzi:
Natl Res Ctr Biotechnol, Dept Cell Biol Immunol & Exptl Oncol, D-38124 Braunschweig, Germany Natl Res Ctr Biotechnol Braunschweig Germany D-38124 aunschweig, Germany
Titolo Testata:
ANTI-CANCER DRUGS
fascicolo: 3, volume: 11, anno: 2000,
pagine: 143 - 148
SICI:
0959-4973(200003)11:3<143:CCIMM->2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED MALIGNANT-MELANOMA; PHASE-II TRIAL; RECOMBINANT INTERFERON-ALPHA; COOPERATIVE-ONCOLOGY-GROUP; RANDOMIZED TRIAL; COMBINATION CHEMOIMMUNOTHERAPY; OUTPATIENT INTERLEUKIN-2; HOME THERAPY; DACARBAZINE; CISPLATIN;
Keywords:
malignant melanoma; combined biochemotherapy; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Schrader, AJ Natl Res Ctr Biotechnol, Dept Cell Biol Immunol & Exptl Oncol, MascheroderWeg 1, D-38124 Braunschweig, Germany Natl Res Ctr Biotechnol Mascheroder Weg 1 Braunschweig Germany D-38124
Citazione:
A.J. Schrader, "Combined chemoimmunotherapy in metastatic melanoma - is there a need for the double?", ANTI-CANC D, 11(3), 2000, pp. 143-148

Abstract

The therapeutic benefit of adding immunotherapeutic agents such as interferon (IFN)-alpha and interleukin (IL)-2 to established single-agent or combination chemotherapy regimens for the treatment of metastatic melanoma has not been proven. On the contrary, recent studies indicate a significantly higher incidence of severe toxic side effects in patients treated with combined biochemotherapy. This article summarizes recent trials using either chemotherapy alone or chemotherapy plus the administration of IFN-alpha and/or IL-2 to evaluate the benefit of a combined biochemotherapy. [(C) 2000 Lippincott Williams & Wilkins.].

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:50:44