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Titolo:
Transthyretin isoleucine-122 mutation in African and American blacks
Autore:
Afolabi, I; Asl, KH; Nakamura, M; Jacobs, P; Hendrie, H; Benson, MD;
Indirizzi:
Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Genet, Indianapolis, IN 46202 USA Wynberg Hosp, Dept Hematol, Cape Town, South Africa Wynberg Hosp Cape Town South Africa pt Hematol, Cape Town, South Africa Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ychiat, Indianapolis, IN 46202 USA Richard L Roudebush Vet Affairs Med Ctr, Indianapolis, IN 46202 USA Richard L Roudebush Vet Affairs Med Ctr Indianapolis IN USA 46202 202 USA
Titolo Testata:
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION
fascicolo: 2, volume: 7, anno: 2000,
pagine: 121 - 125
SICI:
1350-6129(200006)7:2<121:TIMIAA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC AMYLOIDOSIS; VARIANT; FREQUENCY; ILE-122; GENE; POPULATION;
Keywords:
transthyretin; hereditary; amyloidosis; cardiomyopathy; isoleucine-122;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Benson, MD Indiana Univ, Sch Med, Dept Med & Mol Genet, 975 W Walnut St,1B130, Indianapolis, IN 46202 USA Indiana Univ 975 W Walnut St,1B 130 Indianapolis IN USA 46202 A
Citazione:
I. Afolabi et al., "Transthyretin isoleucine-122 mutation in African and American blacks", AMYLOID, 7(2), 2000, pp. 121-125

Abstract

The gene frequency of the transthyretin (TTR) mutation (Val122Ile) was studied in African and African-American populations. The African populations analyzed included the Zulu and Xhosa of South Africa, and Yorubas from the city of Ibadan, Nigeria. The African-American population included patients at the Veterans Affairs (VA) Medical Center, Indianapolis, and newborns froma local hospital in Indianapolis. The Val122Ile TTR mutation was identified in 1 of 55 Zulu, 0 of 34 Xhosa, 0 of 9 Nigerian subjects, 5 of 51 Veteranpatients, and 3 of 103 newborns. Assuming the 2.91 % prevalence in newborns to be the norm, there is a significant increased prevalence in the VA patient population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:48:26