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Titolo:
NMDA receptor participation in control of food intake by the stomach
Autore:
Covasa, M; Ritter, RC; Burns, GA;
Indirizzi:
Washington State Univ, Coll Vet Med, Dept VCAPP, Neurosci Program, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 Program, Pullman, WA 99164 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 278, anno: 2000,
pagine: R1362 - R1368
SICI:
0363-6119(200005)278:5<R1362:NRPICO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTORS; LATERAL HYPOTHALAMUS; GASTRIC-MOTILITY; MEAL TERMINATION; GLUTAMATE; RATS; NUCLEUS; CHOLECYSTOKININ; INNERVATION; SATIATION;
Keywords:
gastric distension; pyloric cuff; satiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Covasa, M Washington State Univ, Coll Vet Med, Dept VCAPP, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 ullman, WA 99164 USA
Citazione:
M. Covasa et al., "NMDA receptor participation in control of food intake by the stomach", AM J P-REG, 278(5), 2000, pp. R1362-R1368

Abstract

We previously reported that MK-801 (dizocilpine), an antagonist of N-methyl-D-aspartate (NMDA)-type glutamate receptors, increased meal size and duration in rats. MK-801 did not increase sham feeding or attenuate reduction of sham feeding by intraintestinal nutrient infusions. These results suggested that the MK-801-induced increase in meal size did not depend on antagonism of postgastric satiety signals. Consequently, we hypothesized that the NMDA antagonist might increase food intake by directly antagonizing gastric mechanosensory signals or by accelerating gastric emptying, thereby reducing gastric mechanoreceptive feedback. To test this hypothesis, we recorded intake of 15% sucrose in rats implanted with pyloric cuffs that could be closed to prevent gastric emptying. Sucrose intake was increased when the pyloric cuffs were open, allowing the stomach to empty. However, intake was notincreased when the pyloric cuffs were inflated, causing gastric retention of all ingested sucrose. Direct measurements of gastric emptying revealed that MK-801 accelerated the emptying of 5-ml loads of 0.9% NaCl and 15% sucrose. Furthermore, MK-801 also accelerated the rate of emptying of freely ingested sucrose regardless of the volume ingested. Taken together with our previous findings, these results indicate that blockade of NMDA receptors with MK-801 does not increase food intake by antagonizing gastric mechanosensation. Rather, it accelerates gastric emptying, and thereby may indirectly reduce gastric mechanoreceptive cues, resulting in prolongation of eating. Modulation of gastric emptying rate by NMDA receptors could play an important role in the control of meal sizes.

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Documento generato il 06/12/20 alle ore 00:05:23