Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Enhanced pressor response to carotid occlusion in commNTS-lesioned rats: possible efferent mechanisms
Autore:
Sato, MA; Menani, JV; Lopes, OU; Colombari, E;
Indirizzi:
UNIFESP, Escola Paulista Med, Dept Physiol, BR-04023060 Sao Paulo, Brazil UNIFESP Sao Paulo Brazil BR-04023060 BCol, BR-04023060 Sao Paulo, Brazil Univ Estadual Paulista, Fac Odontol, BR-14801903 Araraquara, SP, Brazil Univ Estadual Paulista Araraquara SP Brazil BR-14801903 BCara, SP, Brazil
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 278, anno: 2000,
pagine: R1258 - R1266
SICI:
0363-6119(200005)278:5<R1258:EPRTCO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPRAOPTIC NUCLEUS; CONSCIOUS RATS; BRAIN-STEM; ORGANIZATION; VASOPRESSIN; PROJECTIONS;
Keywords:
arterial pressure; nucleus of the solitary tract; baroreceptor; chemoreceptor; potassium cyanide; sympathetic; vasopressin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Colombari, E UNIFESP, Escola Paulista Med, Dept Physiol, 862 Botucatu St, BR-04023060 Sao Paulo, Brazil UNIFESP 862 Botucatu St Sao Paulo Brazil BR-04023060 BCrazil
Citazione:
M.A. Sato et al., "Enhanced pressor response to carotid occlusion in commNTS-lesioned rats: possible efferent mechanisms", AM J P-REG, 278(5), 2000, pp. R1258-R1266

Abstract

Bilateral common carotid occlusion (BCO) over a period of 60 s in conscious rats produces a biphasic presser response, consisting of an early (peak) and late (plateau) phase. In this study we investigated 1) the effects of lesions of the commissural nucleus of the solitary tract (commNTS) on the cardiovascular responses produced by BCO in conscious rats and 2) the autonomic and humoral mechanisms activated to produce the presser response to BCO in sham- and commNTS-lesioned rats. Both the peak and plateau of the presser response produced by BCO increased in commNTS-lesioned rats despite the impairment of chemoreflex responses induced by intravenous potassium cyanide. In sham rats sympathetic blockade with intravenous prazosin and metoprolol, but not vasopressin receptor blockade with the Manning compound, reducedboth components of BCO. In commNTS-lesioned rats the sympathetic blockade or vasopressin receptor blockade reduced both components of BCO. The results showed 1) the sympathetic nervous system, but not vasopressin, is important for the presser response to BCO during 60 s in conscious sham rats; 2) in commNTS-lesioned rats, despite chemoreflex impairment, BCO produces an increased presser response dependent on sympathetic activity associated with vasopressin release; and 3) the increment in the presser response to BCO incommNTS-lesioned rats seems to depend only on vasopressin secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:48:30