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Titolo:
ETA-receptor blockade and ETB-receptor stimulation in experimental congenital diaphragmatic hernia
Autore:
Thebaud, B; De Lagausie, P; Forgues, D; Aigrain, Y; Mercier, JC; Tuan, ADX;
Indirizzi:
Univ Paris 05, AP HP, Hop Cochin, Serv Physiol Explorat Fonct,Assistance Publ Hop P, F-75679 Paris 14, France Univ Paris 05 Paris France 14 tance Publ Hop P, F-75679 Paris 14, France Univ Paris Sud, Hop Antoine Beclere, Serv Reanimat Neonatale, F-92140 Clamart, France Univ Paris Sud Clamart France F-92140 Neonatale, F-92140 Clamart, France Univ Paris 07, Assistance Publ Hop Paris, Hop Robert Debre, Serv Chirurg Viscerale Pediat, F-75019 Paris, France Univ Paris 07 Paris France F-75019scerale Pediat, F-75019 Paris, France Univ Paris 07, Assistance Publ Hop Paris, Hop Robert Debre, Serv Reanimat Pediat, F-75019 Paris, France Univ Paris 07 Paris France F-75019 eanimat Pediat, F-75019 Paris, France Assistance Publ Hop Paris, Ecole Chirurg, F-75005 Paris, France AssistancePubl Hop Paris Paris France F-75005 rg, F-75005 Paris, France CHU Montpellier, Serv Chirurg Viscerale Infantile, F-34000 Montpellier, France CHU Montpellier Montpellier France F-34000 , F-34000 Montpellier, France
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 5, volume: 278, anno: 2000,
pagine: L923 - L932
SICI:
1040-0605(200005)278:5<L923:EBAESI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENT PULMONARY-HYPERTENSION; INHALED NITRIC-OXIDE; GENE-EXPRESSION; OVINE FETUS; LAMB MODEL; RAT MODEL; ENDOTHELIN-1; VASODILATION; PATHOPHYSIOLOGY; NEWBORN;
Keywords:
persistent pulmonary hypertension of the; newborn; nitric oxide; vascular endothelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Tuan, ADX Univ Paris 05, AP HP, Hop Cochin, Serv Physiol Explorat Fonct,Assistance Publ Hop P, 27 Rue Faubourg St Jacques, F-75679 Paris 14, France Univ Paris 05 27 Rue Faubourg St Jacques Paris France 14 France
Citazione:
B. Thebaud et al., "ETA-receptor blockade and ETB-receptor stimulation in experimental congenital diaphragmatic hernia", AM J P-LUNG, 278(5), 2000, pp. L923-L932

Abstract

The aim of this study was to assess the role of nitric oxide (NO) and endothelin (ET)-1 in the pathophysiology of persistent pulmonary hypertension of the newborn in fetal lambs with a surgically created congenital diaphragmatic hernia (CDH). The pulmonary vascular response to various agonists and antagonists was assessed in vivo between 128 and 132 days gestation. Age-matched fetal lambs served as control animals. Control and CDH lambs had similar pulmonary vasodilator responses to acetylcholine, sodium nitroprusside,zaprinast, and dipyridamole. The ETA-receptor antagonist BQ-123 caused a significantly greater pulmonary vasodilatation in CDH than in control animals. The ETB-receptor agonist sarafotoxin 6c induced a biphasic response, with a sustained pulmonary vasoconstriction after a transient pulmonary vasodilatation that was not seen in CDH animals. We conclude that the NO signaling pathway in vivo is intact in experimental CDH. In contrast, ETA-receptor blockade and ETB-receptor stimulation significantly differed in CDH animalscompared with control animals. Imbalance of ET-l-receptor activation favoring pulmonary vasoconstriction rather than altered NO-mediated pulmonary vasodilatation is likely to account for persistent pulmonary hypertension of the newborn in fetal lambs with a surgically created CDH.

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Documento generato il 13/07/20 alle ore 07:33:36